Comparison of clinicopathological characteristics of lymph node positive and lymph node negative breast cancer

Naila Irum Hadi, Qamar Jamal

Abstract


Objective: To record various clinicopathological characteristics of breast cancer (BC) in our population and to find an association between these characteristics and axillary nodal metastasis.

Methods: This cross-sectional study included 150 BC patients from two tertiary care centers in Karachi from 15th February, 2013 to 31st March, 2015. Frequencies, percentages, and odds ratio were estimated to find out an association between various clinicopathological characteristics and lymph node status using SPSS version 20.

Results: Approximately 75.4% patients had axillary lymph node metastasis (‘1-3’ LN = 34.4% and ‘>3’ LN = 44%). Menopausal status (p <0.013), tumor grades (‘II’ p <0.03; ‘III’ p <0.01), and stages (‘III’ p <0.002; ‘IV’ p <0.0001), tumor sizes (‘T2’ p <0.014; ‘T3’ p <0.002), perineural invasion (PNI) (p <0.007), lymphovascular invasion (LVI) (p <0.0001), and skin and nipple invasion (p <0.024) were significant predictors for ‘>3’ LN metastasis. Association of these variables with ‘1-3’ LN involvement was insignificant.

Conclusion: Clinical spectrum of BC remains unchanged in 2016 with most of the patients presenting with high-grade, late-stage advanced disease. Moreover, clinicopathological variables, especially primary tumor size, tumor stage and lymphovascular invasion were significant predictors of >3 lymph node metastasis with high accuracy.

doi: http://dx.doi.org/10.12669/pjms.324.10324

How to cite this:Hadi NI, Jamal Q. Comparison of clinicopathological characteristics of lymph node positive and lymph node negative breast cancer. Pak J Med Sci. 2016;32(4):863-868.   doi: http://dx.doi.org/10.12669/pjms.324.10324

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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