Comparison of serum lipid profile in Type-2 Diabetics withand without retinopathy in Pakistani population

Zulfiqar Ali Amin, Qamar Ul Islam, Muhammad Asim Mehboob

Abstract


Objective: To compare serum cholesterol, TG, HDL-C and LDL-C concentrations between type-2 Diabetes mellitus (DM) patients with retinopathy and without retinopathy and to study association between various modifiable risk factors of Diabetic retinopathy (DR).

Methods: The study included 300 patients with type 2 DM; 140 of them were without DR (Group-I) and 160 were with DR (Group-II). Serum total cholesterol, LDL-C, HDL-C, and TG levels were determined. SPSS 17.0 for windows was used for statistical analysis.

Results: Overall, mean age of study population was 48.86 ± 5.62 years. Subjects with DR were older (P < 0.018), had higher fasting plasma glucose (P < 0.01) and higher HbA1c (P <0.01) concentrations compared with those without DR. Analysis of serum cholesterol, LDL-C, HDL-C and TG among subgroups of patients with no DR, with NPDR and PDR showed statistically significant difference (p <0.01). There was strong positive correlation of severity of DR with BSF, HbA1c, serum LDL-C, total cholesterol and TG.

Conclusion: The serum cholesterol, TG, HDL-C and LDL-C concentrations were found to be significantly deranged in patients with DR as compared to those without DR. 

doi: https://doi.org/10.12669/pjms.326.11056

How to cite this:Amin ZA, Ul-Islam Q, Mehboob MA. Comparison of serum lipid profile in Type-2 Diabetics with and without retinopathy in Pakistani population. Pak J Med Sci. 2016;32(6):1349-1353.   doi: https://doi.org/10.12669/pjms.326.11056

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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