Combined Detection of Urinary Micro Albumin, α1‑microglobulinand N-acetyl-β-D-glucosaminidase in the Early Diagnosis of Diabetic Nephropathy | Zhang | Pakistan Journal of Medical Sciences
 
مبل راحتی صندلی مدیریتی صندلی اداری میز اداری وبلاگدهی گن لاغری بازی اندروید تبلیغات کلیکی آموزش زبان انگلیسی پاراگلایدر مارکت اندروید تور آهنگ محسن چاوشی مسیح و آرش پروتز سینه پروتز باسن پروتز لب میز تلویزیون

Combined Detection of Urinary Micro Albumin, α1‑microglobulinand N-acetyl-β-D-glucosaminidase in the Early Diagnosis of Diabetic Nephropathy

Xuejun Zhang, Hongyan Zhou, Yan Li

Abstract


Objective: To analyze the values of combined detection of urinary micro albumin (mAlb), α1‑microglobulin (α1-MG) and N-acetyl-β-D-glucosaminidase (NAG) in the early diagnosis of diabetic nephropathy (DN).

Methods: Ninety-four patients with early DN who were admitted to the hospital between April 2015 and April 2016 were selected and set as a DN group. Moreover, seventy-six patients with diabetes who were admitted to the hospital in the same period were selected and set as a diabetes group, and sixty-four healthy people were selected as set as a control group. The urinary mAlb, α1-MG and NAG of the three groups were detected. Moreover, the patients were divided into a favorable blood glucose control group and a poor blood glucose control group according to the blood glucose control condition of the patients. The detection results of the three groups were compared and statistically analyzed.

Results: The urinary mAlb, α1-MG and NAG levels of the DN group were significantly higher than those of the diabetes group and control group, and the differences had statistical significance (P<0.05). The detection indicator values of the favorable blood glucose control group were much lower than those of the poor blood glucose control group, and the difference was statistically significant (P<0.05). The positive rate of the combined detection of mAlb, α1-MG and NAG levels was 90.2%, which was much higher than that of single indicator (P<0.05).

Conclusion: Combined detection of urinary mAlb, α1-MG and NAG is sensitive in diagnosing early renal damages in DN patients.

doi: https://doi.org/10.12669/pjms.336.13168

How to cite this:Zhang X, Zhou H, Li Y. Combined Detection of Urinary Micro Albumin, α1‑microglobulin and N-acetyl-β-D-glucosaminidase in the Early Diagnosis of Diabetic Nephropathy. Pak J Med Sci. 2017;33(6):1324-1327.   doi: https://doi.org/10.12669/pjms.336.13168

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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