Oxidative stress and antioxidant parameters in neutropenic patients secondary to chemotherapy | Dogantekin | Pakistan Journal of Medical Sciences Old Website
 

Oxidative stress and antioxidant parameters in neutropenic patients secondary to chemotherapy

Akif Dogantekin, Ali Gurel, Bilal Ustundag, Selcuk Ilhan, Emin Tamer Elkiran

Abstract


Objective: Neutropenia is a serious adverse event that necessitates dosage reduction in patients receiving chemotherapy. In this study, we evaluated the oxidative stress and antioxidant parameters in neutropenic patients after chemotherapy both during the neutropenic period and after successful treatment of neutropenia with filgrastim.

Methods: We studied paraoxonase (PON1), arylesterase (ARE), malondialdehyde (MDA), high-density lipoprotein (HDL), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) in addition to routine biochemical and hematologic parameters. SPSS 12.0 was used for statistical evaluation of data (SPSS, Chicago, IL, USA).

Results: In our study, PON1, HDL, and LDH levels during the period of active neutropenia were statistically significantly higher than these levels were after resolution of neutropenia (P<0.05); MDA and ALP levels were statistically significantly lower during the period of active neutropenia (P<0.05).

Conclusions: Overall, free oxygen radicals (FOR) were increased and antioxidant parameters were decreased with resolution of neutropenia. This is probably due to FOR produced by the increased number of neutrophils rather than tumor burden.

doi: http://dx.doi.org/10.12669/pjms.322.9200

How to cite this:Dogantekin A, Gurel A, Ustundag B, Ilhan S, Elkiran ET. Oxidative stress and antioxidant parameters in neutropenic patients secondary to chemotherapy. Pak J Med Sci. 2016;32(2):309-313.   doi: http://dx.doi.org/10.12669/pjms.322.9200

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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