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Volume 23 |
April - June 2007 (Part-I) |
Number 2 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 23 |
April - June 2007 (Part-I) |
Number 2 |
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Use of AgNOR index in grading and differential
diagnosis of astrocytic lesions of brain
Mulazim Hussain Bukhari1, Shahida Niazi2, Ihsanullah Hashmi3, Samina Naeem4,
Abdul Khalik Abro5, Mohammad Tayyab6, Naseer Ahmad Chaudhry7ABSTRACT
Objective: This study was conducted to see the importance of AgNOR staining in grading and differential diagnosis of Astrocytic lesions.
Methodology: It was a descriptive and prospective study conducted in Department of Pathology King Edward Medical University, from June-December 2002. AgNOR staining was performed on 60 randomly selected brain specimens of Astrocytic lesions including Astrogliosis and Astrocytoma.
Results: AgNOR count, size and dispersion were normal in Astrogliosis, low in Pilocytic Astrocytoma, high in grade II, higher in grade III and highest in grade IV. AgNOR counts of different grades of astrocytoma (2.97±0.96, 3.97±0.43, 6.01±2.74 and 8.01±3.56) were significantly (P< 0.01) greater as compared with counts of normal brain (0.40±0.01), and reactive gliosis (0.60±0.01). There was no statistical difference in normal brain tissues and inflammatory lesions of the brain. AgNOR size and dispersion were of higher grade in significantly greater proportion in malignancy as compared to benign conditions. (P <0.05). AgNOR size and dispersion were normal in Astrogliosis.
Conclusions: Typing of AgNOR count, size and dispersion was found to be an important marker in grading and differential diagnosis of Astrocytic lesions, especially in Astrogliosis and low grade Astrocytoma.
Key words: AgNOR, Astrocytoma, Astrogliosis, Glioblastoma Multiforme.
Pak J Med Sci April 2007 Vol. 23 No. 2 206-210
1. Mulazim Hussain Bukhari,
2. Shahida Niazi,
3. Ihsanullah Hashmi,
4. Samina Naeem,
5. Abdul Khalik Abro,
6. Mohammad Tayyab,
7. Naseer Ahmad Chaudhry
1-4: Department of Pathology,
King Edward Medical University,
5-7: University of Health sciences and
Postgraduate Medical Institute,
Lahore - Pakistan.
Correspondence
Dr. Mulazim Hussain Bukhari, DCP, M.Phill, FCPS
Associate Prof Pathology,
King Edward Medical University, Lahore
26-MOF, GOR-3, Shadman,
Lahore - Pakistan.
E-mail: drmhbukhari@yahoo.com
* Received for Publication: July 3, 2006
* Revision Received: August 23, 2006
* 2nd Revision Received: January 15, 2007
* Revision Accepted: January 18, 2007
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