Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 23

April - June 2007 (Part-I)

Number 2


 

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In vitro synergy of fusidic acid and amikacin against
methicillin resistant Staphlococus aureus

Samia Perwaiz1, Qamaruddin Barakzai2, Badar Jehan Farooqi3, Nasim Sabir4

ABSTRACT
Objective: To test in vitro combination of fusidic acid and amikacin against infections caused by methicillin resistant Staphlococus aureus (MRSA).
Methodology: In vitro study conducted in Department of Pharmacology and Microbiology, Dr. Ziauddin Medical University. The duration of study was March 2004- February 2005. Antibiotic susceptibility testing was done by Kirby Bauer’s disc diffusion method and by minimum inhibitory concentration (MIC) by broth macrodilution and checkerboard technique for synergy. FIC (fractional inhibitory concentrations) were calculated.
Results: MIC of fusidic acid was 0.03-1µg/ml and amikacin 0.5-16µg/ml respectively. The combination of these demonstrated synergy. Evidence of synergy correlated directly with the MICs of fusidic acid and amikacin.
Conclusion: Combination therapy with fusidic acid and amikacin may be a reasonable alternative in the treatment of infections caused by MRSA isolates and encourages clinical evaluation.

KEY WORDS: Vancomycin, Synergism, MRSA, Fusidic Acid, Amikacin.

Pak J Med Sci   April 2007   Vol. 23 No. 2   245-248


1. Dr. Samia Perwaiz
Lecturer
Department of Pharmacology
2. Prof. Qamaruddin Barakzai
Chairman Department of Pharmacology
3. Prof. Badar Jehan Farooqi
Chairperson Department of Microbiology
4. Dr. Nasim Sabir
Assistant professor of Microbiology
1-4: Ziauddin Medical University
Karachi –Pakistan.

Correspondence:

Dr. Samia Perwaiz
St-4 /B, Block 6, Shahrah-I-Ghalib
Clifton- Karachi-Pakistan
E-mail: samiaperwaiz@zmu.edu.pk

* Received for Publication: May 30, 2006
* Revision Received: September 26, 2006
* Revision Accepted: October 4, 2006


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