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Volume 24 |
April - June 2008 (Part-I) |
Number 2 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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Volume 24 |
April - June 2008 (Part-I) |
Number 2 |
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Non-B, Non-C Hepatitis as a cause of Advanced Chronic
Liver Disease requiring medical admission at
a rural centre in Pakistan
Muhammad Ali1, Syed Zafar Abbas2,
Farhat Sultana3,
Waseem Akhtar4, Steve Shaw5, Syed Qamar Abbas6
ABSTRACT
Objectives: To study the frequency and mortality of hepatitis B and C negative chronic liver disease (CLD) at a rural tertiary centre in Pakistan.
Methodology: Data was collected retrospectively from the case notes of all the 176 patients consecutively admitted with advanced CLD in our medical ward during one year period. Patients, who were seropositive for hepatitis B and / or C, were separated from those who were negative for them, and the data was analysed.
Results: Thirty five patients (20%) were negative for both viral markers. They were more likely to die during the admission than those who were seropositive (11% VS 25% - p = 0.029).
Conclusions: A significant proportion of patients with CLD are negative for viral markers. These patients are at higher risk of mortality, and need testing for other causes of CLD as some of them may benefit from curative treatments available.
KEYWORDS: Viral Hepatitis, Chronic Liver Disease, Medical admission, Mortality.
Pak J Med Sci April - June 2008 (Part-I) Vol. 24 No. 2 278-282
1. Muhammad Ali, FCPS, MRCP,
Consultant Physician
2. Syed Zafar Abbas, FRCP, FEBG, FACP,
Consultant Gastroenterologist
3. Farhat Sultana, MBBS,
House Doctor
4. Waseem Akhtar,
Department of Medicine,
Muhammad Medical College Hospital,
Mirpurkhas, Pakistan
5. Steve Shaw, PhD,
Senior Lecturer in Statistics
School of Mathematics and Statistics,
University of Plymouth, Plymouth, UK
6. Syed Qamar Abbas, MA, MBBS;
Associate Specialist, Palliative Care Medicine
St. Clare Hospice, Hastingwood, Essex, UK
Correspondence
Dr. Muhammad Ali
Consultant Physician,
Muhammad Medical College Hospital,
Hyderabad Road, Mirpurkhas
Sindh - Pakistan.
E-mail:
dr_muhammad_ali@hotmail.com;
dr_mohammad_ali@yahoo.com
* Received for publication: December 17, 2007
* Revision Received: March 12, 2008
* Revision Accepted: March 15, 2008
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