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Volume 25 |
April - June 2009 (Part-I) |
Number 2 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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Volume 25 |
April - June 2009 (Part-I) |
Number 2 |
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Hyperglycemia and mortality
in critically ill patients
Mohammad Reza Rezvanfar1, Mohsen Dalvandy2,
Ali Reza Emami3,
Mohammad Rafiee4, Babak Eshratee5
ABSTRACT
Objectives: To analyze the relation between serum glucose concentration and hospital outcome across the critically ill patients.
Methodology: A single-centre, retrospective study was performed at surgical and medical intensive care unit. Admission glucose, mean morning glucose, mean glucose, maximal glucose and time-averaged glucose levels were calculated for each patient. The time-averaged hyperglycemia was defined as the area under the curve above the upper limit of normal, divided by the total length of stay.
Results: Of 300 patients with a median stay of 16 days, the mortality rate was 32%. Mean fasting glucose was 121 mg/dl in survivors versus 160 mg/dl in non survivors (P=0.001). Mean admission glucose was 127 mg/dl in survivors versus 142 mg/dl in non survivors (0.03). Median time-averaged hyperglycemia was 4 mg/dl in survivors versus 17.5 mg/dl in nonsurvivors (P < 0.006). The area under the receiver operator characteristic (ROC) curve was 0.59 for time-averaged glucose and 0.73 for mean fasting glucose.
Conclusions: Whereas time-averaged hyperglycema is a useful assessment for glucose control in critically ill patients, it has no priority to admission glucose and mean fasting glucose for outcome prediction.
KEY WORDS: Critically ill patients, Glucose, Outcome.
Pak J Med Sci April - June 2009 Vol. 25 No. 2 232-237
How to cite this article:
Rezvanfar MR, Dalvandy M, Emami AR, Rafiee M, Eshratee B. Hyperglycemia and mortality in critically ill patients. Pak J Med Sci 2009;25(2):232-237.
1. Mohammad Reza Rezvanfar,
Division of Endocrinology, Internal medicine,
2. Mohsen Dalvandy,
Division of Neurosurgery, Dept. of Surgery,
3. Ali Reza Emami,
Division of Endocrinology, Internal Medicine,
4. Mohammad Rafiee,
5. Babak Eshratee,
Division of Statistics,
Department of Social Medicine,
1-5: University of Arak, Iran.
Correspondence
Dr. Mohammad Reza Rezvanfar
Number7389,
Mellat 5 Alley, Proff. Hesabi St.
Arak, Iran.
E-mail: rezvanfar@gmail.com
* Received for Publication: July 18, 2008
* Accepted: January 20, 2009
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