Pakistan Journal of Medical Sciences

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ISSN 1681-715X

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Volume 25

April - June 2009 (Part-I)

Number  2


 

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Frequency of HLA-B27 antigen in Iranian patients
with brucellosis and it’s relationship with
osteoarticular complication

Seyed Mohammad Alavi1, Mohammad Said Seraj2,
Arash Etemadi3, Moradzadegan H4

ABSRACT

Objectives: To determine frequency of HLA-B27 in brucellosis patients and to investigate a possible association between osteoarticular brucellosis and HLA-B27 antigen.

Methodology: Sixty patients with serologically confirmed brucellosis and 100 healthy controls were screened for HLA-B27 by using standard microlymphocytotoxicity method. Osteoarticular involvement was suggested by clinical presentation and confirmed by nuclear scan. Patients were placed in two groups and compared, patients with osteoarticular involvement (OAP group) and without osteoarticular involvement (OAN group). All data were analyzed by SPSS (version11.5, USA) and using Fisher’s exact X2 test.

Results: Out of total 60 patients with brucellosis 38(63.3%) were male. Mean age of the patients were 36.2±12.3 with the range of 18-65 years. HLA-B27 test was positive in 11 patients (18.33%) with brucellosis, whereas in control group HLA-B27 positivity was 7% (p<0.05).The prevalence of HLA-B27 in OAP and OAN groups was 33.33% and 8.33%, respectively (p<0.05).

Conclusions: The prevalence of HLA-B27 in our brucellosis patients is higher than normal population and there is a significant association between HLA-B27 and brucellar osteoarthritis in the region of study.

KEYWORDS: Brucellosis, Osteoarticular involvement, HLA-B27, Ahwaz.

Pak J Med Sci    April - June 2009    Vol. 25 No. 2    253-256

How to cite this article:

Alavi SM, Seraj MS, Etemadi A, Moradzadegan H. Frequency of HLA-B27 antigen in Iranian patients with brucellosis and it’s relationship with osteoarticular complication. Pak J Med Sci 2009;25(2):253-256.


1. Dr. Seyed Mohammad Alavi, MD
Associated Professor of Medical College
2. Dr. Mohammad Said Seraj, MD
Rheumatology Department, Golestan Hospital
3. Dr. Arash Etemadi, MD
4. Dr. Moradzadegan, MD
Pasteur laboratory
1: Infectious and Tropical Diseases Resaerch Center,
Infectious Disease Ward,
Joundishapour University of Medical Sciences,
Ahwaz,Iran,

Correspondence:

Dr. Seyed Mohammad Alavi,
No: 52, West 11 Avenue, Kianabad, Ahwaz, Iran.
Email: alavi1329dr@yahoo.com

* Received for Publication: April 3, 2008

* Accepted: January 22, 2009



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