Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

HOME   |   SEARCH   |   CURRENT ISSUE   |   PAST ISSUES

-

ORIGINAL ARTICLE

-

Volume 26

April - June 2010

Number  2


 

PDF of this Article

Montelukast versus nigella sativa for
management of seasonal allergic rhinitis:
A single blind comparative clinical trial

Munawar Alam Ansari1, Noor Alam Ansari2, Sameen Afzal Junejo3

ABSTRACT

Objective: To compare the therapeutic role of leukotriene receptor blocker Montelukast with N. Sativa seeds in seasonal allergic rhinitis patients.

Methodology: Comparative uncontrolled single blind clinical assessment was carried out over forty seven untreated adult patients torment from seasonal allergic rhinitis and staring for outpatient management. All patients were chosen from different primary care health centers, registered and were divided in a single-blind approach to obtain Montelukast, 10 mg/day, group I (n=24) and 250 mg/day of N. Sativa, group II (n=23) orally for two weeks. Patients joined-up the study has completed the therapeutic plan.

Results: Montelukast and N. Sativa both demonstrated a significant and early decrease in daytime as well as ophthalmic symptoms, while montelukast showed diminished and late effects on nighttime symptoms when compared with N. Sativa. In addition montelukast has also been showing to cause drug allied side effects like headache, dizziness and heart burn.

Conclusion: It would come into view that N. Sativa is safe and thoroughly free from threat of adverse effects. So it is a liable management alternative for seasonal allergic rhinitis patients.

KEY WORDS: Leukotriene receptor blocker, Montelukast, Nigella Sativa, Seasonal Allergic Rhinitis.

Pak J Med Sci    April - June 2010    Vol. 26 No. 2    249-254

How to cite this article:

Ansari MA, Ansari NA, Junejo SA. Montelukast versus nigella sativa for management of seasonal allergic rhinitis: A single blind comparative clinical trial. Pak J Med Sci 2010;26(2):249-254.


1. Dr. Munawar Alam Ansari. MBBS; M.Phil; Ph.D
Associate Professor
Department of Pharmacology & Therapeutics
2. Dr. Noor Alam Ansari. MBBS; F.C.P.S
Assistant Professor
Department of E.N.T.,
Peoples Medical College for Girls,
Nawabshah - Pakistan.
3. Dr. Sameen Afzal Junejo. MBBS; F.C.P.S
Associate Professor
Department of Ophthalmology
1,3: Liaquat University of Medical & Health Sciences,
Jamshoro,
Sindh - Pakistan.

Correspondence:

Dr. Munawar Alam Ansari, MBBS; M.Phil, Ph.D
E-mail: dr.mnwr@gmail.com

* Received for Publication: November 25, 2009

* Revision Received: February 25, 2010

* Revision Accepted: March 3, 2010



HOME   |   SEARCH   |   CURRENT ISSUE   |   PAST ISSUES

Professional Medical Publications
Room No. 522, 5th Floor, Panorama Centre
Building No. 2, P.O. Box 8766, Saddar, Karachi - Pakistan.
Phones : 5688791, 5689285 Fax : 5689860
pjms@pjms.com.pk