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Volume 26 |
April - June 2010 |
Number 2 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 26 |
April - June 2010 |
Number 2 |
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Effect of Low-dose Folic acid Supplementation versus HRT
and Combination of folic acid and HRT on Plasma Level
of Homocysteine in Postmenopausal WomenShahla Nasrolahi1, Nahid Radnia2, Nosrat Neghab3, Akram Shafie4
ABSTRACT
Objective: This study was designed to evaluate the effect of hormone replacement therapy (HRT) and folic acid supplementation on Homocysteine (Hcy) level in postmenopausal women.
Methodology: This is a randomized clinical trail conducted on 66 postmenopausal women (menopause at least for 2 years) attending Hamedan outpatient Fatemieh teaching hospital. Since March 2006 till April 2007. The patients were randomly divided into four groups. Before studying plasma level of Albumin, total protein, folate, fasting level of plasma Hcy was measured. The patients of first group received folic acid 5mg daily. In the second group of patients took oral conjugated estrogen 0/625mg and medroxy progesterone acetate 2/5 mg daily. In third group the patients received combination of folic acid and HRT and placebo in fourth group. Fasting plasma level of Hcy was measured four weeks later.
Results: Plasma level of Hcy was significantly decreased in group1, 2 and 3(P<0/05) after treatment. There was significant difference between group 1, 3(p=0/026) and 1, 4 (P=0/005) for plasma level of Hcy
Conclusion: HRT and folic acid therapy can reduce plasma Hcy. Combination of both HRT and folic acid supplementation is more effective than HRT or folic acid alone in reduction of hyperhomocysteinemia.
KEYWORDS:
Homocysteine, Folic acid supplementation, Menopause women.Pak J Med Sci April - June 2010 Vol. 26 No. 2 310-313
How to cite this article:
Nasrolahi S, Radnia N, Neghab N, Shafie A. Effect of Low-dose Folic acid Supplementation versus HRT and Combination of folic acid and HRT on Plasma Level of Homocysteine in Postmenopausal Women. Pak J Med Sci 2010;26(2):310-313.
1. Shahla Nasrolahi, MD,
Assistant Prof., Dept. of Gynecology, School of Medicine,
2. Nahid Radnia, MD,
Assistant Prof., Dept. of Gynecology, School of Medicine,
3. Nosrat Neghab, MD,
Resident of Obestetric & Gynecology,
4. Akram Shafie,
Assistant Prof., Dept. of Gynecology, School of Medicine,
1-4: Hamedan University of Medical Science & Health Service,
Hamedan, Iran.
Correspondence:
Nosrat Neghab, MD,
E-mail: drneghab@yahoo.com
* Received for Publication: July 28, 2009
* Accepted: February 2, 2010
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