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Volume 26 |
April - June 2010 |
Number 2 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ORIGINAL ARTICLE |
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Volume 26 |
April - June 2010 |
Number 2 |
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A new valid formula in differentiating iron
deficiency Anemia from ß–thalassemia traitBijan Keikhaei1
ABSTRACT
Objective: To compare the validity of a new index (Hb×RDW×100/ (RBC)2×MCHC) with twelve discriminating functions (DFs) to differentiate iron deficiency anemia (IDA) and beta-thalassemia trait(ß –TT).
Methodology: A total of 823 patients (317 IDA and 506 ß –TT) aged 15 to 35- year- old were enrolled in this study. The diagnostic sensitivity, specificity and other validity parameters were calculated to assess the diagnostic reliability of the novel index [Keikhaei index (KI)] vis-a-vis the other published DFs [Mentzer Index (MI), Green & King Index (G&KI),red cell distribution width index (RDWI), England & Fraser Index (E&FI), Bessman and Feinstein index (B&FI), Telmissani et al index (TI), Srivastava and Bevington index (S&BI), Shine and Lal index (S&LI), Ricerca et al index (RI), Ehsani et al index (EI), Sirdah et al index (SI), and Red Blood Cell Count(RBC)] were calculated in all patients.
Results: All thirteen DFs didn’t have the sensitivity and specificity of 100%. The KI, RDWI, G&KI and E&FI showed the most sensitivity and specificity for both IDA and TT; moreover, the lowest reliable indices belonged to B&FI, S&LI and RI.
Conclusion: According to Youden’s index (YI), DFs in the order of highest to lowest were KI > G&KI > RDWI > E&FI > RBC> M I> EI > TI > SI > S&BI > RI> S&LI >B&FI.
KEYWORDS
: ß–thalassemia trait, Iron deficiency, Anemia, Sensitivity & specificity, Hypochromia.Pak J Med Sci April - June 2010 Vol. 26 No. 2 368-373
How to cite this article:
Keikhaei B. A new valid formula in differentiating iron deficiency Anemia from ß–thalassemia trait. Pak J Med Sci 2010;26(2):368-373.
1. Bijan Keikhaei,
Associate Prof of Research Center for
Thalassemia & Hemoglobinopathy,
Ahwaz Jondishapour,
University of Medical science,
Ahwaz –Iran
Correspondence:
Dr. Bijan Keikhaei,
Associate Prof of Research Center for
Thalassemia & Hemoglobinopathy,
Ahwaz Jondishapour, University of Medical science,
Ahwaz – Iran.
E–Mail: keikhaeib@yahoo.com
* Received for Publication: October 9, 2009
* Revision Received: January 19, 2010
* Revision Accepted: January 31, 2010
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