Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 23

April - June 2007 (Part-II)

Number 3


 

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Serum Uric Acid Concentration in patients with Type 2
Diabetes Mellitus during Diet or Glibenclamide Therapy

Isam Hamo Mahmood1

ABSTRACT
Objective: To investigate serum uric acid concentration in patients with type 2 diabetes mellitus.
Methodology: This is a case control study conducted in Al-Wafa Diabetic Center in Mosul over a period of one year starting from January 1, 2005 to January 1, 2006. Serum glucose concentration and uric acid concentration were measured in both control and patient’s groups (group 1 patients on diet therapy, group 2 patients on glibenclamide therapy and group 3 involve naturopathic patients).
Results: Serum glucose concentration was high in the diabetic groups as compared with the control group (P<0.001). Serum uric acid concentration was lower in the diabetic groups as compared with the control group but do not reach a significant level (P>0.2) except in group-3 (P<0.05). A negative correlation was reported between hyperglycemia and uric acid concentration of the different groups.
Conclusion: Serum uric acid concentration is slightly reduced in type 2 diabetic patients particularly in the complicated patients with peripheral neuropathy and this may be due to the oxidative stress that decreases the antioxidant capacity of the body involving uric acid.

KEY WORDS: Type 2 diabetes mellitus, Fasting Blood Sugar, Uric acid, Oxidative stress.

Pak J Med Sci   May - June 2007   Vol. 23 No. 3    361-365


1. Dr. Isam Hamo Mahmood,
Head of Pharmacology,
Department College of Medicine,
University of Mosul,
Mosul – Iraq.

Correspondence

Dr. Isam Hamo Mahmood,
E-mail: isam_abdulaziz@yahoo.com

* Received for Publication: June 19, 2006
* Revision Received: December 7, 2006
* Accepted: December 28, 2006



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