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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 23 |
April - June 2007 (Part-II) |
Number 3 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 23 |
April - June 2007 (Part-II) |
Number 3 |
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Morphometeric study of primary sensory neurons
following surgical repair of sciatic nerve
Mohammad Ali Atlasi1, Mehdi Mehdizadeh2,
Mohammad Hadi Bahadori3, Mohammad Taghi Joghataei4ABSTRACT
Objective: Peripheral nerve transection causes neuonal cell death. Effects of surgical nerve repair on survival of primary sensory neurons was to be studied.
Methodology: This is a morphometeric study of dorsal root ganglion neurons of adult rats by Hoechst staining conducted at Neuroscience laboratory and Cellular and Molecular Center, Medical faculty, Iran University of Medical Sciences. Models of direct epineurial suture and using of nerve guidance channel of polyvinilydin flourid (PVDF) were used and neuronal number and volume of dorsal root ganglion of L5 were evaluated by morphometeric method.
Results: Direct epineurial suture technique decreased sensory neuronal loss and both direct epineurial suture & using of nerve guidance channel decreased reduction of the ganglion volume.
Conclusion: Present study showed distal segment of peripheral nerve is essential for neuronal survival, but surgical nerve repair could not completely prevent from neuronal cell death.
KEY WORDS: Dorsal root ganglion neurons, Sciatic nerve, Surgical nerve repair, Morphometery.
Pak J Med Sci May - June 2007 Vol. 23 No. 3 366-369
1. Dr. Mohammad Ali Atlasi
Department of Anatomy,
Medical College, Kashan University of Medical Sciences,
Kashan – Iran.
2. Dr. Mehdi Mehdizadeh
3. Dr. Mohammad Hadi Bahadori
Department of Anatomy,
Gilan University of Medical Sciences,
Rasht – Iran.
4. Dr. Mohammad Taghi Joghataei
2& 4: Department of Anatomy,
Iran University of Medical Sciences,
Tehran – Iran.
Correspondence
Dr. Mohammad Ali Atlasi,
Email: matlasi@hotmail.com
ma_atlasi@yahoo.com
* Received for Publication: June 28, 2006
* Accepted: December 29, 2006
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