Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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Volume 23

April - June 2007 (Part-II)

Number 3


 

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Acquired Aplastic anemia:
Treatment in a developing country

Shaheena Hanif1, Farah Naz2, Emad uddin Siddiqui3, Jamal Raza4

ABSTRACT
Objective: The aim of this study was to evaluate the clinical presentation of aplastic anemia as well as to assess the efficacy of Cyclosporin -A in patients with aplastic anemia.
Methodology: This is a hospital based interventional study. During the three year study period, 44 children were enrolled. Mean age was 9.3 years and there was a male predominance.
Results: Most common clinical presentation was anemia and bleeding. Four children died before therapy was started. Cyclosporin-A was started in 40 patients. Eleven patients died before completion of therapy and three patients were lost to follow-up. Out of 26 patients who completed therapy, 11 were cured and 9 were responders while 6 were non responders according to the selected criteria.
Conclusion: In developing third world countries like Pakistan majority of the patients with aplastic anemia cannot afford BMT. Alternative modalities of treatment must therefore be looked into. Cyclosporin-A seems to be a reasonable therapeutic option in such cases.

KEY WORDS: Aplastic Anemia, Cyclosporin- A, Immunosuppression.

Pak J Med Sci   May - June 2007   Vol. 23 No. 3    370-374


1. Dr. Shaheena Hanif,
Senior Registrar,
Civil Hospital Karachi
2. Dr. Farah Naz,
3. Dr. Emaduddin Siddiqui,
2-3: Intructor Pediatric,
Aga Khan Hospital,
Karachi - Pakistan.
4. Dr. Jamal Raza,
Associate Professor,
National Institute of Child Health,
Islamabad - Pakistan.

Correspondence

Dr. Emad uddin Siddiqui
E-mail: emaduz@yahoo.com

* Received for Publication: September 22, 2006
* Revision Received: November 7, 2006
* Revision Accepted: December 28, 2006



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