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Volume 23 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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Volume 23 |
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Number 3 |
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Haemorheological changes in cancer
patients on chemotherapy
Caroline Edijana Omoti1, Evarista Osime2
ABSTRACT
Objective: To assess the rheological changes in haematological and non-haematological cancer patients’ pre and post chemotherapy.
Patients and Method: It is a prospective study of 50 patients comprising 16(32%) haematological and 34(68%) non-haematological cancers of various types from March to December 2005 at University of Benin Teaching Hospital, Nigeria. Rheologic parameters estimated by the various specific diagnostic methods were determined in cancer patient’s pre and post chemotherapy. The rheological tests estimated were relative plasma viscosity (RPV) measured by means of a capillary viscometer, whole blood viscosity (WBV), erythrocyte sedimentation rate (ESR) and plasma fibrinogen concentration (PFC) estimated by the Ingram’s Clot weight method.
Results: The RPV in pre chemotherapy (p=0.006) and WBV in post chemotherapy (p=0.0231) patients measured revealed a significant difference when compared to controls. The fibrinogen concentration (P<0.0001) and ESR values (P<0.0001) were significantly increased in cancer patients when compared to controls.
Conclusion: We conclude that total reduction of hyperviscosity and hyperfibrinogenaemia may contribute to effective treatment strategies in cancer patients.
KEY WORDS: Haemorheology, Cancer, Chemotherapy.
Pak J Med Sci May - June 2007 Vol. 23 No. 3 313-317
1. Dr. Caroline Edijana Omoti
MB.BS, FMC PATH,
Consultant Haematologist,
Department of Haematology,
2. Evarista Osime
Med. Lab. Scientist/ Lecturer
AIMLT (Haem), FIMLT (Microbiology)
MSc (Microbiology).
1-2: University of Benin Teaching Hospital
P.M.B. 1111, Benin City, Nigeria.
Correspondence
Dr. Caroline Edijana Omoti,
Consultant Haematologist,
Department of Haematology,
University of Benin Teaching Hospital,
Nigeria.
E-mail: ediomoti@yahoo.com
* Received for Publication: October 28, 2006
* Revision Received: February 14, 2007
* Revision Accepted: March 14, 2007
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