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Volume 23 |
April - June 2007 (Part-II) |
Number 3 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 23 |
April - June 2007 (Part-II) |
Number 3 |
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Expression and function of integrin associated protein
(IAP)/CD47 in human articular cartilage
Orazizadeh Mahmoud1, Salter Donald2
ABSTRACT
Background: Integrin-associated protein (IAP) /CD47, a member of immunoglobulin super family (IgSF), is expressed in a variety of cell types. In the present work, the expression pattern of IAP/CD47 in normal and osteoarthritis (OA) human articular cartilage and its role in mechanotransduction pathway following mechanical stimulation have been studied.
Methods: Using immunohistochemistry and standard western blotting the in vivo and in vitro expression pattern of CD47 in normal and OA human articular cartilage was assessed.The role of CD47 in mechanotransduction was evaluated by using an electrophysilogical method.
Results: Immuno histochemical studies showed a similar very strong expression pattern of CD47 in both normal and OA cartilage. Electrophysilogical experiments showed a role for CD47 in chondrocyte response to mechanical stimulation.
Conclusion: Very strong expression pattern of CD47 in both normal and OA chondrocyte may be a result of its critical function/s in chondrocyte homeostasis and it appears that CD47 is important in regulation of the chondrocyte response to mechanical stimulation.
KEY WORDS: CD47/IAP, Integrin, Chondrocyte, Osteoarthritis (OA).
Pak J Med Sci May - June 2007 Vol. 23 No. 3 432-437
1. Dr. Orazizadeh Mahmoud,
Department of Anatomical Sciences, Faculty of Medicine,
Ahwaz Jundi-Shapour University of Medical Sciences,
Ahwaz – IRAN.
2. Dr. Salter Donald,
University of Edinburgh,
The Queen’s Medical Research Institute,
47 Little France Crescent, Edinburgh, Scotland, U.K.
Correspondence
Dr. Orazizadeh Mahmoud,
Email: M_orazizadeh@yahoo.com
* Received for Publication: June 19, 2006
* Accepted: January 4, 2007
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