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Volume 24 |
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Number 3 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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Volume 24 |
April - June 2008 (Part-II) |
Number 3 |
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Comparison of therapeutic values between leukotriene
receptor antagonist (montelukast) and inhaled glucocorticoide
(beclomethasone propionate) in bronchial asthma of adults
Shahab Ahmad Khan1, Zahid Yaseen Hashmi2
ABSTRACT
Objective: To compare therapeutic values between leukotriene receptor antagonists (Monteleukast) and inhaled glucocorticoide (Beclomethasone) in naturally occurring bronchial asthma of adults.
Methodology: A total of 765 patients suffering from various respiratory disorders were examined. All of them were adults and belonged to the male gender. Comparison of therapeutic values between the administration of Monteleukast and inhalation of Beclomethasone in naturally occurring bronchial asthma in adults was studied.
Results: Out of 765 patients examined, sixty (7.8%) were diagnosed to be asthmatics on the basis of characteristic symptoms, physical and clinical examinations and Lab tests. The patients had persistent cough, wheezing, chest tightness, suffocation and shortness of breath, anxiety and nocturnal paroxysms. They represented 36.6% businessmen, 28.3% textile workers, 18.3% teachers, 10% hospital employees and 6.6% students. All of them were hospitalized for two weeks in the Ali ward of the Divisional Headquarters (DHQ) hospital; Faisalabad. The first group of 30 patients selected randomly was treated for 8 weeks with Monteleukast and the second group of the remaining 30 patients with inhalation of Beclomethasone for the same period. The enzyme, Alanin Transaminase (ALT) was found elevated in all the 30 patients treated with Monteleukast (P<0.001). The Peak Expiratory Flow Rate (PEFR) of the patients treated with both Monteleukast and Beclomethasone was measured. The mean values of PEFR values obtained with Monteleukast differed favourably for the 1st and 3rd week (P<0.05) and relatively so during later weeks which was also statistically similar to that of Beclomethasone. The age of the patients appeared to remain uninfluenced with the protocols of the two medicines.
Conclusions: The treatment with Montelukast resulted in rise of the enzyme, ALT in all the asthmatic patients and their PEFR values showed more favorable results for the 1st and 3rd weeks and relatively so around 6th week and later which was statistically similar to that of Beclomethasone. The age of the patients showed no variations in PEFR values obtainrd with the two types of medication used.
KEY WORDS: Bronchial asthma, Montelukast, Beclomethasone.
Pak J Med Sci April - June 2008 (Part-II) Vol. 24 No. 3 399-405
How to cite this article:
Khan SA, Hashmi ZY. Comparison of therapeutic values between leukotriene receptor antagonist (montelukast) and inhaled glucocorticoide (beclomethasone propionate) in bronchial asthma of adults. Pak J Med Sci 2008;24(3):399-405.
1. Dr. Shahab Ahmad Khan, DTCD, FCPS,
Senior Medical Officer.
2. Dr. Zahid Yaseen Hashmi, MCPS, FCPS,
Professor of Medicine,
1,2: Allied and DHQ Hospitals,
Punjab Medical College,
Faisalabad – Pakistan.
Correspondence
Dr. Shahab Ahmad Khan,
E-mail: mzamankhan2005@yahoo.com
* Received for Publication: November 28, 2007
* Revision Received: March 13, 2008
* 2nd Revision Received: March 28, 2008
* Final Revision Accepted: April 1, 2008
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