Pakistan Journal of Medical Sciences

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ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 24

April - June 2008 (Part-II)

Number  3


 

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Effect of compound 11g as a novel selective cox-2
inhibitor on movement disorders in a rat
model of Parkinson’s disease

Mehdi Shafiee Ardestani1, Hadi Fathi Moghaddam2,Mostafa Saffari3

ABSTRACT

Objective: To test the effect of selective COX-2 inhibitors compound 11g on movement disorders of Parkinson’s disease (PD).

Methodology: In the study the rat left substantia nigra pars compacta (SNc) has been destroyed using electrical lesion (10 Sec; 1mA DC) to generate PD model. Then 11g (2, 4mg/kg) and celecoxib a well known and standard COX-2 inhibitor (4, 8mg/kg) have been administrated orally to parkinsonian rats. Then the rigidity and locomotor activity of parkinsonian rats were evaluated.

Results: Both selective COX-2 inhibitors decreased the rigidity and improved the locomotor activity of parkinsonian rats P<0.05 as compared to the control groups.

Conclusions: Based on the results of the Locomotor activity and rigidity tests using parkinsonian rats, we found that compound 11g had remarkable rigidity-improving effect.

KEY WORDS: Compound (11g), Celecoxib, Electrical lesion, Parkinson’s disease, Inflammation, Cyclooxygenase -2.

Pak J Med Sci    April - June 2008 (Part-II)    Vol. 24 No. 3    436-441

How to cite this article:

Ardestani MS, Moghaddam HF, Saffari M. Effect of compound 11g as a novel selective cox-2 inhibitor on movement disorders in a rat model of Parkinson’s disease. Pak J Med Sci 2008;24(3): 436-41.


1. Mehdi Shafiee Ardestani,
Department of Medicinal Chemistry
and Radiopharmacy,
Faculty of Pharmacy,
Tehran University of Medical Sciences,
Tehran, Iran.
2. Hadi Fathi Moghaddam,
Department of Physiology,
School of Medicine and Physiology Research Center,
Joundishapour University of Medical Sciences,
Ahwaz, Iran.
3. Mostafa Saffari,
Department of Pharmaceutics,
Faculty of Pharmacy,
Shahid Beheshti University of Medical Sciences,
Tehran, Iran.

Correspondence

Dr. Mehdi Shafiee Ardestani
Email: shafieeardestani@razi.tums.ac.ir

* Received for Publication: October 3, 2007
* Revision Received: March 25, 2008
* Revision Accepted: April 1, 2008



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