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Volume 25 |
April - June 2009 (Part-II) |
Number 3 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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Volume 25 |
April - June 2009 (Part-II) |
Number 3 |
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The Effect of Pentoxifylline in semen preparation
for intrauterine insemination
Tooba Mehrannia1
ABSTRACT
Objective: Pentoxifylline (PX) is a methyxanthin derivative that influences the sperm motility characteristics. and has been reportedly effective in preserving sperm motility in vitro. This study was undertaken to evaluate whether addition of pentoxifylline to the previously standardized in-vitro treatment of semen improves the percentage of pregnancies after homologous IUI.
Methodology: The study involved 110 infertile couples (66 classified infertile for male factors and 44 for other factors) who underwent a total of 300 cycles of homologous IUI: 202 for male factor infertility and 98 for other factors.
Results: Out of the 202 cycles performed for male factor infertility, 122 underwent the standard preparation of semen, pregnancy rate were 11.5%. While 80 had a semen preparation with pentoxifylline. The pregnancy rate were 27.5% better with pentoxifylline preparation (P<0.05). Abortions and malformations were equally distributed in the standard treatment and in the pentoxifylline group.
Conclusion: Our results demonstrate that pentoxifylline may be used for improving the male infertility treatment program.
KEY WORDS: Intrauterine insemination (IUI), Pentoxifylline, Semen Preparation.
Pak J Med Sci April - June 2009 (Part-II) Vol. 25 No. 3 359-363
How to cite this article:
Mehrannia T. The Effect of Pentoxifylline in semen preparation for intrauterine insemination. Pak J Med Sci 2009;25(3): 359-363.
1. Tooba Mehrannia Ph.D
Assistant Professor,
Infertility Center,
Kermanshah University of Medical Sciences,
Kermanshah, Iran.
Correspondence
Tooba Mehrannia Ph.D
E-mail: toobamehrannia@gmail.com
* Received for Publication: November 10, 2008
* Accepted: April 15, 2009
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