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Volume 23 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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Volume 23 |
January - March 2007 |
Number 1 |
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Response of Booster Dose of Cuban Recombinant Hepatitis-B
Vaccine in Nonresponder and Hyporesponder ChildrenHossein Dahifar1, Farideh Mousavi2, Aboulphazl Ghorbani3
ABSTRACT
Background: Acute hepatitis B infection can debilitate a patient for weeks and occasionally has a fatal outcome, while chronic infection is a major threat to the individual.
Objective: To assess response of nonresponder and hyporesponder children to booster dose of Cuban recombinant hepatitis B vaccine.
Subjects and Methods: An interventional, descriptive study has been conducted on children who had been immunized with Cuban recombinant Hepatitis B vaccine and their antibody titers were <10mIU/ml (nonresponder) and 10-100mIU/ml (hyporesponder) administered booster dose of the same vaccine in their Deltoid muscles.
Results: The response of 141 children with the mean age of 1.9 years to booster dose of vaccine were 94.3% and 100% vaccinees with the first and second booster dose of vaccination respectively. The anti-HBs titer in nonresponders and hyporesponders were 468±346 and 783± 346mIU/ml respectively with significant differences between two groups (P=0.001).
Conclusion: This study demonstrate moderately increase antibody production in the majority of vaccinees with single supplementary vaccine.
KEY WORDS: Hepatitis B virus, Vaccination, Cuban vaccine, Hyporesponders, Nonresponders.
Abbreviations used
anti = Antibody HBsV = Hepatitis B surface antigen virus HBc = Hepatitis B core antigen
HLA= Human Leukocyte antigens miu/ml = Milli international units per milliliter
Pak J Med Sci January - March 2007 Vol. 23 No.1 23-26
1. Dr. Hossein Dahifar MD
2. Farideh Mousavi MD
3. Aboulphazl Ghorbani MD
1-3: Shaheed Beheshti University of Medical Sciences and Health Services,
Shohada Medical Center,
Pediatric Department, Tajrish Square,
Tehran-Iran.Correspondence:
Dr. Hossein Dahifar,
No. 50, Kouhestan Hashtoom,
Pasdaran Ave,
Tehran-19537,
Tehran-Iran.
E-mail: dr_dahifar@yahoo.com* Received for Publication: December 17, 2005
* Accepted: August 31, 2006
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