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Volume 23 |
January - March 2007 |
Number 1 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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Brief Communication |
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Volume 23 |
January - March 2007 |
Number 1 |
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Comparative study of Corticotrphin vs.
Vigabatrin therapy in Infantile SpasmRiaz Ahmed1
ABSTRACT
Twenty six patients were diagnosed as infantile spasm, on the basis of fixed criteria and they were divided into symptomatic (17 patients) and cryptogenic (9 patients) groups according to history, presentation and investigations. Corticotrophin as Tetracosactrin was given to eleven patients and fifteen patients received Vigabatrim (VGB). The response to VGB was significant (73%) compared to steroids (63%), irrespective of the etiology, thus emphasizing that VGB could be considered as the first line therapy for infantile spasm.
KEY WORDS: Infantile spasm (IS), Adrenocorticotrophin (ACTH), Tetracosactin, Vigabatrin (VGB), Electroencephalography (EEG).
Pak J Med Sci January - March 2007 Vol. 23 No.1 141-144
1. Dr. Riaz Ahmed,
Consultant Paediatric Neurologist,
Royal Hospital,
P.O Box: 1331,
Postal Code: 111-seeb,
Muscat,
Oman.Correspondence:
Dr. Riaz Ahmed
E-Mail: paedbrain@yahoo.com* Received for Publication: August 17, 2006
* Accepted: September 14, 2006
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