Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 24

January - March 2008

Number  1


 

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Clinical presentation of late
haemorrhagic disease of Newborn

Rehana Majeed1, Yasmeen Memon2, Farrukh Majeed3

ABSTRACT

Objectives: To observe the clinical presentation of late haemorrhagic disease of the newborn (LHDNB), and clinical improvement after the administration of vitamin K1.

Methodology: This is a prospective descriptive study. All the children older than seven days who presented with bleeding were admitted in pediatrics ward of Isra University Hyderabad from April 2006 to April 2007 were included. Data collection was done by means of detailed proforma. Analysis was done on SPSS version 11.

Results: Thirty five cases were included. Commonest site of bleeding was subcutaneous followed by oral and injection site. Mean age of late haemorrhagic disease of newborn was 109 days and minimum age of presentation was 28 days. Common clinical presentations were irritability, convulsions, poor reflexes and poor feeding. Mostly recovery was within 24 hours after vit K.

Conclusion: Late HDN results in severe hemorrhage especially hemorrhage in the central nervous system. Administration of Vitamin K (1mg, IM) at birth can present these severe complications.

KEY WORDS: Vitamin K deficiency bleeding (VKDB), Late haemorrhagic disease of newborn (LHDN), Intraventriculer haemorrhage, Vit K, Prothrombin Time (PT), Activated partial thromboplastin time (aPTT).

Pak J Med Sci    January - March 2008    Vol. 24 No. 1    52-55


1. Dr. Rehana Majeed, FCPS
Assistant Professor,
Pediatric Department,
Isra University, Hyderabad, Pakistan.
2. Dr. Yasmeen Memon, FCPS
Pediatric Department,
Liaquat University of Medical and Health Science,
3. Dr. Farrukh Majeed,
Department of Physiology,
Dow University Karachi, KARACHI.

Correspondence

Dr. Rehana Majeed
E- Mail: drrehanamajeed@yahoo.com

* Received for Publication: July 19, 2007

* Accepted: November 30, 2007



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