Hyperhomocysteinemia and Bone Mineral
Density: A Case - Control Study

Majid Mobasseri¹, Akbar Aliasgharzadeh², Zinolabedin Ebrahimzadeh³,
Farzad Najafipoor⁴, Mitra Niafar⁵, Naser Aghamohammadzadeh⁶, Amir Bahrami⁷

ABSTRACT

Objectives: To find out whether homocysteine has a direct effect on bone or it is an innocent bystander? The study was designed to investigate probable role of homocysteine on bone mineral density (BMD).

Methodology: This a case-control study wherein, 30 patients with at least one densitometry criterion of osteoporosis in femoral neck or lumbar spine were enrolled as the case group along with another 30 normal subjects with normal BMD, as the control group. The patients of the two groups were matched for their ages and sex. In all eligible patients BMD was measured by DEXA and fasting serum homocysteine level were measured by Enzyme Immunoassay Kit.

Results: The mean of serum level of homocysteine were 11.67±4.38 and 11.97±3.09 ́mol/l in control and case groups respectively. The difference between two groups was not significant (P=0.761). Serum homocysteine level and BMC of various areas in case and control groups had no significant correlation [lumbar spine in control group (r= 0.025, p=0.9), lumbar spine in case group (r=0.071, p=0.716), femoral neck in control group (r=0.276, p=0.147), femoral neck in case group (r=0.001, p=0.998)].

Conclusion: Despite numerous studies about direct effect of homocysteine on increase of osteoporotic fracture risk, our study did not show a correlation between serum level of homocysteine and BMD. Due to multiplicity of factors affecting bone density, final conclusions need extensive investigations with attention to other confounding factors.

KEYWORDS: Homocysteine, Osteoporosis, Bone Mineral Density.

Pak J Med Sci    January - March 2009    Vol. 25 No. 1    91-96

How to cite this article:

Mobasseri M, Aliasgharzadeh A, Ebrahimzadeh Z, Najafipoor F, Niafar M, Aghamohammadzadeh N, et al. Hyperhomocysteinemia and Bone Mineral Density: A Case-Control Study. Pak J Med Sci 2009;25(1):91-96.

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1. Dr. Majid Mobasseri,
2. Dr. Akbar Aliasgharzadeh,
Associated Professor,
3. Dr. Zinolabedin Ebrahimzadeh,
Internist in Hashtrod Iran
4. Dr. Farzad Najafipoor,
5. Dr. Mitra Niafar,
6. Dr. Naser Aghamohammadzadeh,
1,4,5: Assistance Professor,
7. Dr. Amir Bahrami,
Professor,
1-7: Faculty of Medicine,
Endocrine and Metabolism Research Team,
Emamreza Teaching Hospital,
Tabriz University of Medical Sciences,
Tabriz – Iran.

Correspondence

Dr. Akbar Aliasgharzadeh,
Associated Professor, Faculty of Medicine,
Endocrine and Metabolism Section,
Emamreza Teaching Hospital,
Golgasht Avenue Tabriz – Iran.
E-mail: asgharzadeha@tbzmed.ac.ir

* Received For Publication: April 24, 2008
* Revision Received: November 1, 2008
* Revision Accepted: November 11, 2008

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