Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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Clinical Case Series

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Volume 25

January - March 2009

Number  1


 

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Prednisolone as a new approach for treatment
of HTLV-1 associated polyneuropathy

Nemati Karimooy H1, Derakhshan M2, Rezaee SA3, Mahmoud Hosseini4

ABSTRACT

Objective: We have previously shown the implication of HTLV-1 in polyneuropathy in a HTLV-1 endemic area in Mashhad. Treatment with corticosteroids (prednisolone and methylprednisolone) have been recommended for HTLV-1 associated diseases. In the current study we attempted to evaluate the efficiency of prednisolone in HTLV-1 associated polyneuropathy

Methodology: All recognized cases of HTLV-1 polyneuropathy admitted to Imam Reza Hospital (between 1999-2004) were selected for the study. The other common causes of polyneuropathy were excluded using biochemical, hematological, and neurologic examination. Anti-HTLV-1 IgG assays were carried out and positive anti-HTLV-1 results were then confirmed by Western Blot Analyzing. All of the HTLV-1 associated polyneuropathy patients were given prednisolone, 1mg/kg and tapering 5mg/ per week, for three month.

Results: Muscle force and paresthesia of all cases were returned to normal pattern. This therapeutic regimen led to reduction of disease severity. Muscle force increased to V/V and paresthesia of all cases were severely decreased.

Conclusion: The results of present study suggest that immunosuppressive treatment is very effective for HTLV-1 associated polyneuropathy patients.

KEYWORDS: HTLV-1, Polyneuropathy, Prednisolone, Immunosuppressive.

Pak J Med Sci    January - March 2009    Vol. 25 No. 1    142-145

How to cite this article:

Nemati KH, Derakhshan M, Rezaee SA, Hosseini M. Prednisolone as a new approach for treatment of HTLV-1 associated polyneuropathy . Pak J Med Sci 2009;25(1):142-145.


1. Nemati Karimooy H,
Neurology Department, Imam Reza Hospital,
Mashhad University of Medical Sciences (MUMS),
Mashhad, Iran.
2. Derakhshan M,
3. Rezaee SA,
2-3 Department of Virology,
Ghaem Hospital, MUMS, Mashhad,
Iran and Buali Research Centre in MUMS.
4. Mahmoud Hosseini,
Department of Physiology, School of Medicine,
Mashhad University of Medical Sciences (MUMS),
Mashhad, Iran.

Correspondence:

Nemati Karimooy H,
Email: nematih@mums.ac.ir

* Received for Publication: July 18, 2008
* Accepted: November 15, 2008



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