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Volume 23 |
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Volume 23 |
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Number 4 |
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Echocardiographic evaluation of patients
with systemic lupus erythematosusShahid Hameed1, Lamees Mahmood Malik2, Saqib Shafi3, Sumaira Azeem4, Atif Shahzad5
ABSTRACT
Objective: Cardiac disease occurs in various forms and is a common cause of death in systemic lupus erythematosus. The objective was to detect cardiac abnormalities by transthoracic echocardiography and determine their association in SLE patients.
Methods: We conducted a transthoracic echocardiographic study in 48 inpatients with systemic lupus erythematosus. Clinical and serological evaluation to confirm the diagnosis of lupus was done in all patients.
Results: There were 44 women (91.6%) and 4 men with a mean age of 26 years. Anti ds DNA was positive in 34 patients (68.75%).Transthoracic echocardiography revealed abnormality in 28 patients (58.33%).Of these, 16 patients(57%) had pericardial involvement with variable amount of effusion. Twelve patients (43%) had some valvular involvement and some degree of myocardial systolic dysfunction was found in12 patients (43%). Only 4 patients (14%) had all three abnormalities. Anti ds DNA was positive in 71% of patients with cardiac abnormalities.
Conclusions: Cardiac involvement is common in patients with systemic lupus erythematosus. Serological abnormalities had an association with cardiac abnormalities, and were found to be more prevalent in young patients.
Key words: Echocardiography, Cardiac abnormalities, Systemic lupus erythematosus.
Pak J Med Sci July - September 2007 Vol. 23 No. 4 497-500
1. Dr. Shahid Hameed
Assistant Professor Cardiology,
2. Dr. Lamees Mahmood Malik
Department of Dermatology
3. Dr. Saqib Shafi
4. Dr. Sumaira Azeem
5. Dr. Atif Shahzad
1,3: Punjab Institute of Cardiology, Lahore – Pakistan.
2. PGMI and Lahore General Hospital, Lahore - Pakistan.
4,5: King Edward Medical University and Mayo Hospital,
Lahore – Pakistan.
Correspondence
Dr. Shahid Hameed,
E mail: shahdham@yahoo.com
* Received for Publication: February 6, 2007
* Revision Received: February 21, 2007
* Revision Accepted: April 5, 2007
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