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Volume 23 |
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Number 4 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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Volume 23 |
July - September 2007 |
Number 4 |
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Increased serum iron associated with coronary heart
disease among Nigerian adultsBose E. Orimadegun1, John I. Anetor2, Deborah A. Adedapo3,
Grace O Taylor4, Jude A. Onuegbu5, Japhet M. Olisekodiaka6ABSTRACT
Objective: To examine the concentrations of serum iron and some risk factors of coronary heart disease in Nigerians with evidence of Coronary Heart Disease.
Methodology: The concentration of serum iron, the plasma cholesterol level, the hip-waist ratio and body mass index of 70 patients with evidence of CHD seen at a Cardiology Unit of a Specialist Hospital in Ibadan and 70 healthy subjects selected randomly were determined. Subjects were grouped into four age categories and three socioeconomic classes (high, middle and low).
Results: The age of the subjects ranged from 31-70 years with the mean of 53.6±11.0 years and 50.1±10.5 years for patients and controls respectively. The mean serum iron and plasma cholesterol levels were significantly higher among patients than controls irrespective of age and sex (p<0.05). No correlation was found between serum iron and the variables; plasma cholesterol level, age, body mass index (BMI) and hip-waist ratio.
Conclusion: Significantly higher serum iron levels found in patients with evidence of CHD appears to support the hypothesis that there is a potential association between iron status and CHD.
KEY WORDS: Serum iron, Plasma Cholesterol, Coronary heart disease, Body mass index, Hip-waist ratio.
Pak J Med Sci July - September 2007 Vol. 23 No. 4 518-522
1. Bose E. Orimadegun,
2. John I. Anetor,
3. Deborah A. Adedapo,
4. Grace O. Taylor (Ph.D),
5. Jude A. Onuegbu (Ph.D),
Department of Biomedical Sciences,
6. Japhet M. Olisekodiaka,
1,2,4: Department of Chemical Pathology,
College of Medicine, University of Ibadan, Nigeria.
3: Dept. of Pharmacology
College of Medicine, University of Ibadan, Nigeria.
5,6: Ladoke Akintola University of Technology,
Ogbomosho – Nigeria.
Correspondence
Bose E Orimadegun,
E-mail: orimadegunbose@yahoo.co.uk
* Received for Publication: November 8, 2006
* Accepted: April 2, 2007
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