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Volume 24 |
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Number 4 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 24 |
July - September 2008 |
Number 4 |
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activity of certain drugs in CombinationIn vitro
Ghaleb Mohammad Adwan1, Bassam Ali Abu-Shanab2,
Kamel Mohammad Adwan3
ABSTRACT
Objectives: This study has been done to evaluate the interaction between ethanolic extracts of Rhus coriaria (seed), Psidium guajava (Leaf), Lawsonia inermis (Leaf) and Sacropoterium spinosum (seed) and antimicrobial drugs including oxytetracycline HCl, enrofloxacin, gentamicin sulphate and sulfadimethoxine against four clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).
Methodology: Evaluation of the interaction between ethanolic extracts and different antimicrobial agents has been done using well-diffusion method.
Results: It showed that ethanolic extracts increase the inhibition zones of oxytetracycline HCl, gentamicin sulphate, and sulfadimethoxine, while combinations between these plant extracts and enrofloxacin decrease inhibition zone.
Conclusion: This study probably suggests the possibility of concurrent use of these antimicrobial drugs and plant extracts in combination in treating infections caused by S. aureus strains or at least the concomitant administration may not impair the antimicrobial activity of these antibiotics.
KEYWORDS: Ethanolic plant extracts, Antibiotics, Drugs, Synergism, Antagonism, Staphylococcus aureus, MRSA.
Pak J Med Sci July - September 2008 Vol. 24 No. 4 541-544
How to cite this article:
Adwan GM, Abu-Shanab BA, Adwan KM.In vitro activity of certain drugs in Combination with plant extracts against Staphylococcus aureus infections. Pak J Med Sci 2008;24(4):541-4.
1. Ghaleb Mohammad Adwan,
Department of Biology and Biotechnology,
An-Najah N. University,
P. O. Box (7)-Nablus,
Palestine.
2. Bassam Ali Abu-Shanab,
Faculty of Veterinary Medicine,
An-Najah N. University,
Nablus, Palestine.
3. Kamel Mohammad Adwan,
Department of Biology and Biotechnology,
An-Najah N. University,
P. O. Box (7)-Nablus, Palestine.
Correspondence
Ghaleb Mohammad Adwan,
E-mail: adwang@najah.edu
* Received for Publication: November 24, 2007
* Revision Received: May 14, 2008
* Revision Accepted: May 22, 2008
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