Anti-HBs in Immunized Children with Cuban Hepatitis B
Vaccine and Impact of Booster Dose After five Years

Hossein Dahifar¹, Aboulfazl Ghorbani², Farideh Mousavi³

ABSTRACT

Objectives: Hepatitis B virus infection and associated diseases are a major public health problem. This study was planned to find out the persistence of antibody against hepatitis B surface antigen in Iranian vaccinated children after five years.

Methodology: Anti-HBs titers in a group of healthy good – responder children who were vaccinated with Cuban hepatitis B vaccine in infancy were measured after five years. Children with antibody titers <100mlU/ml were revaccinated and retested after four weeks.

Results: Mean anti-HBs titers in 68 children (29 females, 39 males) were 482.1mIU/mL at six months after the third dose of primary vaccination and 153mIU/mL at five years later. Total mean anti-HBs titers in 36 (52.9%) children out of 68 (17 females, 19 males) were 38.3mIU/ml and 4(5.8%) of 68 children (two of each sexes) had no detectable antibody after five years. Total mean anti-HBs titers in these hypo- responder and non- responder were 774.3mIU/mL and 625.5mIU/mL respectively after booster dose.

Conclusion: In a group of children, who were immunized with Cuban hepatitis B vaccine from birth, anti-HBS titers fell at 6.5 years of age and almost half of children became hypo responder or no responder and their anti-HBs titers developed secondary rise after booster vaccination. All children showed immunologic memory to a booster dose.

KEY WORDS: Hepatitis B virus, Anti-HBs, Vaccine.

Pak J Med Sci    July - September 2008    Vol. 24 No. 4    571-574

How to cite this article:

Dahifar H, Ghorbani A, Mousavi F. Anti-HBs in Immunized Children with Cuban Hepatitis B Vaccine and Impact of Booster Dose After five Years. Pak J Med Sci 2008;24(4):571-4.

---

1. Hossein Dahifar M.D.
Associate Professor,
2. Aboulfazl Ghorbani, M.D.
Booali Hospital, Marivan, Iran
3. Farideh Mousavi M.D.
Assistant Professor,
1&3: Shaheed Beheshti University of Medical Sciences,
Shohada Medical Center, Pediatrics Department,
Tajrish Sq. Tehran, Iran

Correspondence

Hossein Dahifar
Postal Address: No. 50,
Kouhestan Hashtoom, Pasdaran Ave. 19537,
Tehran, Iran
E-mail: dr_dahifar@yahoo.com

* Received for Publication: June 12, 2007
* Revision Received: July 3, 2007
* 2nd Revision Received: May 19, 2008
* Final Revision Accepted: May 21, 2008

---

HOME   |   SEARCH   |   CURRENT ISSUE   |   PAST ISSUES

Professional Medical Publications
Room No. 522, 5th Floor, Panorama Centre
Building No. 2, P.O. Box 8766, Saddar, Karachi - Pakistan.
Phones : 5688791, 5689285 Fax : 5689860
pjms@