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Volume 24 |
July - September 2008 |
Number 4 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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Volume 24 |
July - September 2008 |
Number 4 |
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Comparision of Single and Multidose of Methotrexate
in Medical Treatment of Ectopic pregnancy
Mahvash Zargar1, Taghi Razi2, Mojgan Barati3
ABSTRACT
Objective: The purpose of this study was to compare the efficacy and safety of two regimens of methotrexate for medical treatment of ectopic pregnancy.
Methodology: In this prospective randomized clinical trial 100 women clinically suspected to have un ruptured ectopic pregnancy were randomly (One by one) treated with single (50mg/m2) and multi dose (1mg/kg MTX+ 0.1mg/kg folinic acid) Methotrexate (50 cases in each group). Results of two groups were compared.
Results: The overall success rate of treatment was 94%. The use of single dose was associated with a greater chance of response to medical management than multi dose. (97% versus 91%). The single dose regimen was associated with greater side effects. Women who experienced side effects were more likely to have successful treatment regardless of regimen. Three percent of patients had serum B hCG >10000IU/ml and in 5% of cases fetal heart reported in adnexal mass. Both these groups were much more responsive to single dose treatment.
Conclusions: Efficacy of single dose in medical treatment of Ectopic pregnancy is better than multi dose regimen.
KEY WORDS: Ectopic pregnancy, Vaginal sonography, Methotrexate.
Pak J Med Sci July - September 2008 Vol. 24 No. 4 586-589
How to cite this article:
Zargar M, Razi T, Barati M. Comparision of Single and Multidose of Methotrexate in Medical Treatment of Ectopic pregnancy. Pak J Med Sci 2008;24(4):586-9.
1. Mahvash Zargar,
2. Taghi Razi,
3. Mojgan Barati, MD,
1-3: Assistant Professor,
Ahwaz Jondishapour University of Medical Science,
Ahwaz – Iran.
Correspondence
Mahvash Zargar,
Ob&Gyn Ward,
Emam Khomaini Hospital,
24-Metry Street,
Ahwaz – Iran.
E-mail: navaein@yahoo.com
brati_m@yahoo.com
* Received for Publication: January 30, 2008
* Revision Received: February 27, 2008
* Revision Accepted: May 31st, 2008
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