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Volume 24 |
July - September 2008 |
Number 4 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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Volume 24 |
July - September 2008 |
Number 4 |
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Effects of dexamethasone in primary intracerebral
hemorrhage in the South West of Iran
Sharafadinzadeh N1, Baghebanian SM2,
Pipelzadeh M 3,
Moravej Ale Ali A4, Ghanavati P5
ABSTRACT
Objective: Previous study revealed the value of dexamethasone in the treatment of vasogenic edema associated with brain tumor and abscess. However there are poor documented studies about its usefulness in primary intracerebral hemorrhage. In this study we evaluated dexamethasone effects in primary intracerebral hemorrhage.
Methodology: In a double blind randomized placebo-controlled clinical trial we evaluated 200 intracerebral hemorrhage cases between 40 to 80 years old whom were admitted at Golestan Hospital (Ahwaz, IR) between March 2002 And March 2003. They were divided in two groups; dexamethasone (N=100) and placebo (N=100). Then mortality, GI bleeding, fever, electrolytes disturbances, hypertension and hyperglycemic status were analyzed in two groups. Ethical considerations were employed and subjects were followed by appropriate statistical methods for 21 days to assess the major outcomes.
Results: Mortality was much higher in the dexamethasone group; Dexamethasone group (49.3%) and placebo (23.4%) and also fever was higher seen in the dexamethasone group; dexamethasone group (40.2%) and placebo group (24.7%) but there was not any significant statistical difference between two groups as regards other complications.
Conclusion: Dexamethasone is widely used for cerebral edema associated conditions but in this study we saw that it’s complications in intracerebral hemorrhage such as increasing fever and mortality are significantly higher. Hence it use for treatment of primary intracerebral hemorrhage should be reconsidered.
KEYWORD: Primary intracerebral hemorrhage, Dexamethasone, Complication.
Pak J Med Sci July - September 2008 Vol. 24 No. 4 502-505
How to cite this article:
Sharafadinzadeh N, Baghebanian SM, Pipelzadeh M, Moravej-Ale A, Ghanavati P. Effects of dexamethasone in primary intracerebral hemorrhage in the South West of Iran. Pak J Med Sci 2008;24(4):502-5.
1. Naser Sharafadinzadeh, MD,
Assistant Professor of Neurology,
2. Seyed Mohammad Baghebanian, MD,
Resident of Neurology
3. Mohamad Pipelzadeh, MD,
General Physician
4. Armaghan Moravej Ale Ali, MD,
General Physician
5. Parvin Ghanavati, MS,
Nurse
Clinical Research Center,
1-5: Golestan Hospital,
Ahwaz Jundishapour University of Medical Sciences,
Ahwaz – Iran.
Correspondence
Dr. Naser Sharafadinzadeh
Assistant Professor of Neurology
Neurology Department
Jundishapour University of Medical Sciences
Ahwaz, Iran.
. Email:
sharafaddinzadeh@yahoo.com
* Received for Publication: October 20, 2007
* Accepted: June 8, 2008
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