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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 24 |
July - September 2008 |
Number 4 |
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Treatment outcome of hyperprolactinaemic
infertility with carbegoline in sub Saharan AfricaAdesiyun Adebiyi Gbadebo1, Ameh Nkiruka2, Ozed-Williams Ijeoma3,
Ojabo Austin4, Umar Hajara5ABSTARCT
Objectives: Hyperprolactinaemia is a known cause of infertility. We explored the efficacy of carbegoline, the long acting dopamine agonist that was recently introduced into our medical practice.
Methodology: Seventy six patients with infertility secondary to hyperprolactinaemia were studied over a period of 20 weeks each. All the patients had carbegoline twice weekly for eight weeks. Two dosage regimen were used based on the pretreatment prolactin level; less than 50ng/ml had 0.25mg twice weekly (n=58) and 50ng/ml and above 0.5mg twice weekly (n=18).
Results: Normalization of prolactin level was achieved in 75 (98.7%) patients. At the end of the study period, there was resumption of menstrual flow in 10 (76.9%) of the 13 patients that were amenorrhoiec and all the 39 (100%) patients that were oligomenorrhoeic had their normal menstrual cycle restored. Resumption of ovulatory cycles occurred in 87.7% of those with anovulatory cycles. Of the 76 patients, 69 (90.8%) got pregnant during the 20 weeks study. However, out of the 69 that got pregnant, 13 (18.8%) got pregnant while on carbegoline therapy. There was no case of carbegoline resistance or discontinuation recorded in this study.
Conclusion: Carbegoline is a cost effective first line therapy in the management of infertile women with hyperprolactinaemia.
KEYWORDS: Carbegoline, Female infertility, Hyperprolactinaemia, Pregnancy.
Pak J Med Sci July - September 2008 Vol. 24 No. 4 512-516
How to cite this article:
Gbadebo AA, Nkiruka A, Ijeoma OW, Austin O, Hajara U. Treatment outcome of hyperprolactinaemic infertility with carbegoline in sub Saharan Africa. Pak J Med Sci 2008;24(4):512-6.
1. Adesiyun Adebiyi Gbadebo FWACS
2. Ameh Nkiruka FWACS
3. Ozed-Williams Ijeoma FWACS
4. Ojabo Austin FMOOG
5. Umar Hajara FWACS
1-5: Department of Obstetrics and Gynaecology,
Ahmadu Bello University Teaching Hospital,
Shika-Zaria Kaduna State,
Kaduna - Nigeria.
Correspondence
Dr. A.G. Adesiyun,
P. O. Box 204,
Kaduna, Nigeria.
Email: biyi.adesiyun@yahoo.com
* Received for Publication: March 5, 2008
* Accepted: June 16, 2008
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