Published by : PROFESSIONAL MEDICAL PUBLICATIONS
ISSN 1681-715X
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ORIGINAL ARTICLE
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Volume 25
July - September 2009
Number 4
Maternal plasma lipid concentrations in first
trimester of pregnancy and risk of sever preeclapmsiaAkhavan Setareh1, Modarres Gilani Mitra2, Borna Sedigheh3,
Shahghaibi Shoaleh4, Yousefinejad Vahid5, Shahsavari Siroos6ABSTRACT
Objective: The role of abnormal lipid profile as a risk factor in pathology of pre-eclampsia is controversial. We investigated the relationship between early pregnancy plasma lipid concentrations and risk of severe pre-eclampsia.
Methodology: It was a prospective cohort study, in which one thousand maternal blood samples were collected at first trimester of pregnancy. We selected 63 women who developed severe preeclampsia from the cohort and 280 normotensive as control group matched with pre-eclamptic group. Plasma lipid concentrations were measured enzymatically. Data was analyzed with student t-test, and Relative risk with 95% confidence interval was calculated.
Results: The risk of severe preeclampsia among women with serum triglyceride level >175 mg/dl was 13.14 fold the ones with serum triglyceride level <100 (95% CI 1.84-265.4).
Conclusion: This study has showed that early pregnancy dyslipidemia is associated with an increased risk of severe pre-eclampsia.
KEYWORDS: Lipids, Pregnancy, Severe Pre-eclampsia.
Pak J Med Sci July - September 2009 Vol. 25 No. 4 563-567
How to cite this article:
Setareh A, Mitra MG, Sedigheh B, Shoaleh S, Vahid Y, Siroos S. Maternal plasma lipid concentrations in first trimester of pregnancy and risk of sever preeclapmsia. Pak J Med Sci 2009;25(4):563-567.
1. Akhavan Setareh, MD,
Assistant Professor of Obstetric and Gynecology,
2. Modarres Gilani Mitram, MD,
3. Borna Sedigheh MD,
2,3: Associate Professor of Obstetric and Gynecology,
Tehran University of Medical Sciences,
Imam Khomeini Hospital, Tehran.
4. Shahghaibi Shoaleh, MD,
Assistant Professor of Obstetric and Gynecology,
5. Yousefinejad Vahid MD,
General Practitioner, Researcher,
6. Shahsavari Siroos, MSc,
Instructor,
1,3,4-6: Kurdistan University of Medical Sciences,
Behsat Hospital, Sanandaj, Iran.
Correspondence
Dr. Akhavan Setareh,
E-mail: S_akhavan2007@yahoo.com
* Received for Publication: December 3, 2008
* Revision Received: June 10, 2009
* Revision Accepted: June 22, 2009
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