Pakistan Journal of Medical Sciences

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ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 26

July - September 2010

Number  3


 

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Study on HLA-DQB1*03 allele associated with
women human papilloma virus (HPV) lesions

Abdollahi Fard S1, Solmaz Ilkhchoui2,
Reza Ghotaslou3, Omid Mashrabi4

ABSTRACT

Objectives: The specific HLA alleles associated with HPV differ among various study groups. It has been suggested that women carrying HLA-DQw3 antigen encoded by DQB 1*03, are predisposed to develop cervical cancer. The aim of this study was to determine HLA-DQB1*03 alleles in HPV lesions.

Methodology: In a cross-sectional and analytical study, Hundred women enrolled into the study. Twenty of them had abnormal Pap smear, Fifty patients had condyloma lesions and 30 patients with malignant lesions. HLA–DQB*03 and HPV infection was evaluated by PCR.

Results: PCR of HPV was positive in 50 women with condyloma lesions and 8 women with malignant lesion (p< 0.001). HLA–DQB*03 was positive in 9 women with abnormal Pap smear , 18 women with condyloma lesions and 7 women with malignant lesion(P= 0.261). Positive PCR of HPV was significantly higher in women with condyloma lesions than other women (p< 0.001). Mean age of patients with positive PCR of HPV was significantly lower than patients with negative PCR of HPV (P= 0.001). Mean age of patients with positive HLA–DQB*03 was 42.08 + 11.48 year and mean age of patients with negative HLA–DQB*03 Was 43.83 +11.21 year (P= 0.462). HLA–DQB*03 was positive in 34% of patients.

Conclusion: In this study, we do not see any significant correlation between HPV infection and HLA–DQB*03 in the studied women.

KEY WORDS: HLA-DQB1*03, Human Papilloma Virus, Polymerase Chain Reaction, kondilomaei lesions, Cervical Cancer, Pap smear.

Pak J Med Sci    July - September 2010    Vol. 26 No. 3    571-576

How to cite this article:

Abdollahi Fard S, Ilkhchoui S, Ghotaslou R, Mashrabi O. Study on HLA-DQB1*03 allele associated with women human papilloma virus (HPV) lesions. Pak J Med Sci 2010;26(3):571-576


1. Abdollahi Fard S
Associated professor of Obstetrics & Gynecology,
2. Solmaz Ilkhchoui
Gynecologist,
3. Reza Ghotaslou
Associated Professor of Microbiology,
4. Omid Mashrabi
1-4: Faculty of Medicine,
Tabriz University of Medical Sciences, Tabriz, Iran.

Correspondence:

Mashrabi Omid,
No. 20, Shakeri Alley, Jahad Ave. Imam Street,
Ajabshir, East Azarbayjan Province, Iran.
E-mail: mashrabi1383@yahoo.com

* Received for Publication: September 24, 2009
* Accepted: April 7, 2010



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