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Volume 26 |
July - September 2010 |
Number 3 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 26 |
July - September 2010 |
Number 3 |
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The cognitive dysfunctions of multiple sclerosis:
Do we face from the early terms?Nilufer Cetisli Korkmaz1, Levent Sinan Bir2,
Emre Baskan3, Tuba Can4, Talip Cabuk5ABSTRACT
Objectives: The diversity of physical and cognitive impairments seen in Multiple Sclerosis (MS), make it difficult to make the definition and classification of physical and cognitive disabilities and to identify the factors that influence neurorehabilitation programs and outcomes. In the view of the complexities of both Multiple Sclerosis (MS) and the rehabilitation process, this preliminary study’s aim was to determine the cognitive dysfunctions by conducting on early term relapsing-remitting MS (RRMS) patients.
Methodology: Cognitive performances of 27 early term RRMS patients and 27 individually s ex-age matched volunteer healthy controls (HC) were compared. Each patient underwent a complete clinical assessment, including depression, disability and comprehensive cognitive function [attention: Stroop tests, memory and perception: Wechsler Memory Scale-Revised (WMS-R) subtests].
Results: There were statistically significant differences between groups for all subtests of Stroop (p<0.05), WMS-Digit Span (p<0.05), WMS-Logical Memory (p<0.001) and WMS-Visual Reproduction (p<0.001). The significance remained while the depression’s effect was controlled. There was a statistically significant difference between visual reproduction of immediate (WMS-VRI) and delayed (WMS-VRD) memory in RRMS patient group (p<0.05). In the light of results it was recorded that, deficient cognitive performance is predominantly apparent in early term RRMS patients.
Conclusion: Cognitive assessment and rehabilitation must be in the context of multidisciplinary rehabilitation of RRMS patients from the early terms.
KEY WORDS:
Relapsing-Remitting Multiple Sclerosis (RRMS), Cognitive Dysfunctions, Stroop Color-Word Interference Test, Wechsler Memory Scale-Revised (WMS-R), Attention, Memory, Depression, EDSS, Multidisciplinary, Rehabilitation.Pak J Med Sci July - September 2010 Vol. 26 No. 3 623-628
How to cite this article:
Korkmaz NC, Bir LS, Baskan E, Can T, Cabuk T. The cognitive dysfunctions of multiple sclerosis: Do we face from the early terms? Pak J Med Sci 2010;26(3):623-628
1. Nilufer Cetisli Korkmaz, PT. PhD,
School of Physical Therapy and Rehabilitation.
2. Levent Sinan Bir, MD. PhD,
Professor, Dept. of Neurology, Faculty of Medicine.
3. Emre Baskan, PT. PhD
School of Physical Therapy and Rehabilitation.
4. Tuba Can, PT. MSc,
School of Physical Therapy and Rehabilitation.
5. Talip Cabuk, Psychologist, Mediko.
1-5. Pamukkale University, Denizli, Turkey.Correspondence:
Nilufer Cetisli Korkmaz, PT. Ph.D.
School of Physical Therapy and Rehabilitation,
Pamukkale University,
Rektorluk Binasi B Kati
20070 Kinikli-Denizli, TURKEY.
Email: niluferc75@yahoo.com
* Received for Publication: December 8, 2009
* Revision Received: December 10, 2009
* Revision Accepted: April 11, 2010
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