Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 26

July - September 2010

Number  3


 

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Histopathological grading and staging in liver biopsies
of Hepatitis-C patients and their association with ALT levels

Shuja Izhar Syed1, Saleem Sadiq2

ABSTRACT

Objective: To perform the histological evaluation of liver biopsies and see its association with the serological levels of ALT.

Methodology: This was a prospective study based on liver biopsies of fifty hepatitis C patients, whose serum ALT levels were also estimated. H and E stained slides were examined to determine the histological activity and fibrosis score.

Results: Grade 1 activity was found in 44% of patients; whereas 42% had an activity of grade 3. About 44% cases having grade 1 activity had a mean ALT of 52.3 U/L while 42% cases having severe activity had a mean ALT of 76.14 U/L. The present study revealed a significant relationship of ALT with fibrosis (p < 0.005). A steady and proportional rise in mean age with increasing score of fibrosis stage was also evident.

Conclusion: Higher ALT levels are associated with more pronounced forms of necroinflammatory activity; however normal ALT level does not rule out severity of the disease suggesting that all such patients require liver biopsy to unearth clinically subtle but advanced liver disease.

KEY WORDS: Liver Biopsy, Hepatitis C, Necroinflammatory Activity, Grade, Stage, ALT.

Pak J Med Sci    July - September 2010    Vol. 26 No. 3    644-648

How to cite this article:

Syed SI, Sadiq S. Histopathological grading and staging in liver biopsies of Hepatitis-C patients and their association with ALT levels. Pak J Med Sci 2010;26(3):644-648


1. Dr. Shuja Izhar Syed, BBS, M.Phil
Assistant Professor,
Department of Pathology,
Bqai Medical University,
Karachi-Pakistan.
2. Dr. Saleem Sadiq MBBS, M.Phil,
Professor,
Department of Pathology,
Basic Medical Sciences Institute,
Jinnah Postgraduate Medical Center,
Karachi-Pakistan.

Correspondence:

Dr. Shuja Izhar Syed, MBBS, M.Phil
Assistant Professor,
Department of Pathology,
Baqai Medical University,
Karachi-Pakistan.
E-mail: shujaizhar@yahoo.com

* Received for Publication: August 19th, 2009

* Revision Received: April 22nd, 2010

* Revision Accepted: April 25th, 2010



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