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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 26 |
July - September 2010 |
Number 3 |
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Histopathological grading and staging in liver biopsies
of Hepatitis-C patients and their association with ALT levelsShuja Izhar Syed1, Saleem Sadiq2
ABSTRACT
Objective: To perform the histological evaluation of liver biopsies and see its association with the serological levels of ALT.
Methodology: This was a prospective study based on liver biopsies of fifty hepatitis C patients, whose serum ALT levels were also estimated. H and E stained slides were examined to determine the histological activity and fibrosis score.
Results: Grade 1 activity was found in 44% of patients; whereas 42% had an activity of grade 3. About 44% cases having grade 1 activity had a mean ALT of 52.3 U/L while 42% cases having severe activity had a mean ALT of 76.14 U/L. The present study revealed a significant relationship of ALT with fibrosis (p < 0.005). A steady and proportional rise in mean age with increasing score of fibrosis stage was also evident.
Conclusion: Higher ALT levels are associated with more pronounced forms of necroinflammatory activity; however normal ALT level does not rule out severity of the disease suggesting that all such patients require liver biopsy to unearth clinically subtle but advanced liver disease.
KEY WORDS:
Liver Biopsy, Hepatitis C, Necroinflammatory Activity, Grade, Stage, ALT.Pak J Med Sci July - September 2010 Vol. 26 No. 3 644-648
How to cite this article:
Syed SI, Sadiq S. Histopathological grading and staging in liver biopsies of Hepatitis-C patients and their association with ALT levels. Pak J Med Sci 2010;26(3):644-648
1. Dr. Shuja Izhar Syed, BBS, M.Phil
Assistant Professor,
Department of Pathology,
Bqai Medical University,
Karachi-Pakistan.
2. Dr. Saleem Sadiq MBBS, M.Phil,
Professor,
Department of Pathology,
Basic Medical Sciences Institute,
Jinnah Postgraduate Medical Center,
Karachi-Pakistan.
Correspondence:
Dr. Shuja Izhar Syed, MBBS, M.Phil
Assistant Professor,
Department of Pathology,
Baqai Medical University,
Karachi-Pakistan.
E-mail: shujaizhar@yahoo.com
* Received for Publication: August 19th, 2009
* Revision Received: April 22nd, 2010
* Revision Accepted: April 25th, 2010
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