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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 22 |
October - December 2006 |
Number 4 |
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Correlation of fasting insulin resistance
indices with clinical parameters of metabolic
syndrome in type 2 diabetic subjectsAsher Fawwad1, Rashida Qasim2, M. Zafar Iqbal Hydrie3,
Abdul Basit4, Zahid Miyan5, Asma Gul6ABSTRACT
Objectives: To identify the insulin resistance by various available insulin resistance indices and to see their correlation with clinical parameters of metabolic syndrome in type2 diabetic population.
Methods: All type 2 diabetic subjects having age 30 years or more were selected with exclusion criteria (hepatic, renal or cardiac impairment). Insulin resistance was assessed by components of metabolic syndrome as defined by ATP III and by using fasting insulin resistance indices i.e. HOMA, QUICKI and McAuley. The correlation between clinical parameters of metabolic syndrome and insulin resistance indices were seen by calculating Pearson’s coefficient.
Results: One hundred eighteen subjects were selected (62.4% males and 37.6% females). Mean BMI was 27.8±4.9kg/m2. Mean systolic B.P was 129.7±19.7. Mean diastolic B.P was 80.9±10.8. Mean LDL level was 103 ± 27.6. Mean HOMA was 4.1. Mean QUICKI index was 0.3276. Mean McAuley was 6.79. The results indicate that various Insulin resistance indices have strong and significant correlations in between them but not significantly correlated with all clinical parameters of metabolic syndrome.
Conclusion: Correlation of fasting insulin resistance with clinical parameters of metabolic syndrome is lost when people develop diabetes.
Key Words: HOMA, QUICKI, McAuley, Insulin Resistance, Type 2 diabetes.
Pak J Med Sci October - December 2006 Vol. 22 No. 4 433-437
1. Dr. Asher Fawwad MBBS
Incharge Research Department,2. Dr. Rashida Qasim, PhD.
Chairperson, Z.A School of Medical Technology
Sindh Institute of Urology& Transplantation, Karachi.3. Dr. M. Zafar Iqbal Hydrie MBBS
Research Officer4. Dr. Abdul Basit FRCP
Professor of Medicine, Head of Department,
Medical Unit - IV, Baqai Medical University
Baqai Institute of Diabetology and Endocrinology.5. Dr. Zahid Miyan MCPS
Senior Registrar6. Ms. Asma Gul MSc.
Consultant Statistician1,3-6: Research Department,
Baqai Institute of Diabetology and Endocrinology
Plot 1-2, II-B, Block 2, Nazimabad-2,
Karachi-74600, Pakistan.Correspondence
Dr. Asher Fawwad MBBS
Email: bideresearch@hotmail.com* Received for Publication: February 4, 2006
* Accepted: June 20, 2006
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