Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 22

October - December 2006

Number 4


 

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Corticosteroids effect on vestibular
neuritis symptom relief

Ali Akbar Rezaie1, Farnaz Hashemian2, Nima Rezaie3

ABSTRACT

Background and objectives: Vestibular neuritis is the second most frequent cause of peripheral vertigo. Adding corticosteroids to symptomatic treatment regimen is effective in shortening the symptomatic period of vestibular neuritis but there are controversies on administration of corticosteroids for this condition. The aim of this study was to investigate the corticosteroids effect on vestibular neuritis symptom relief.

Methods: In this double blind placebo controlled clinical trial on 40 patients with vestibular neuritis who presented at Hamedan Sina Hospital neurology ward, all subjects signed an informed consent. The participitants were randomly assigned to intervention (n=20) and control group (n=20). The intervention group received dimenhydrinate 50 mg bid as well asdexamethasone 6mg tid for three days. Controls received deminhidrinate 50 mg bid plus placebo for three days. At 24, 48, and 72 hour the result of Caloric test and patients symptom were recorded.

Results: The mean duration of symptom relief had significant difference in two groups. At 24 hour of initiation of therapy vertigo, nystagmus and nausea were relived in 5, 16, 17 of intervention group and in 1, 5, 2 of control group, respectively (P<0.001).

Conclusion: Corticosteroids are effective in shortening the symptomatic period of vestibular neuritis.

KEY WORDS: Vestibular neuritis, Vertigo, Corticosteroids.

Pak J Med Sci October - December 2006 Vol. 22 No. 4 409-411


1. Dr. Ali Akbar Rezaie
Assistant Professor
Department of Neurology

2. Dr. Farnaz Hashemian
Assistant Professor
Department of Otolaryngology and
Head and Neck Surgery

3. Nima Rezaie
Medical Student.

1-3: Hamedan University of Medical Science
Hamedan, IRAN.

Correspondences:
Dr. Ali Akbar Rezaie
E-Mail: aliakbarrezaei51@yahoo.com

* Received for Publication: December 16, 2005

* Accepted: May 15, 2006


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