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Volume 23 |
October - December 2007 (Part-I) |
Number 5 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 23 |
October - December 2007 (Part-I) |
Number 5 |
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The Mitochondrial K-ATP Channel Opener, Diazoxide,
protects brain against Ischemia-Reperfusion Injury in the Rat
Mehdi Mehdizadeh1, Mansooreh Soleimani2,
Majid Katebi3, Hamid Reza Pazouki4,
Mohamad Taghi Joghataei5, Noor Ahmad Latifi6, Masoomeh
Bakhshayesh7
ABSTRACT
Objective: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. The objective of this research was to study effects of the mitochondrial K-ATP (MAK) channel regulators on neuronal cell population and neurological function after ischemia reperfusion in the rat.
Methodology: Rats were temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without MAK channel regulators.
Results: The normal cell count of neuronal population significantly increased in the K-ATP channel opener (diazoxide) treated ischemia-reperfusion group compared with the control group. Cell count and neurological function scores were dose dependent to MAK channel regulators in vivo.
Conclusions: Our results showed that diazoxide treatment leads to better preservation of cortical neurons in rat.
KEYWORDS
: K-ATP Channel, Ischemia reperfusion Injury, Diazoxide.Pak J Med Sci October - December 2007 (Part-I) Vol. 23 No. 5 741-746
1. Mehdi Mehdizadeh
2. Mansooreh Soleimani
3. Majid Katebi
4. Hamid Reza Pazouki
5. Mohamad Taghi Joghataei
6. Noor Ahmad Latifi
7. Masoomeh Bakhshayesh
1,2,5: Department of Anatomy,
School of Medicine,
3: Department of Medicine,
School of Medicine, New York University,
New York , NY , USA
4: Department of Physiology,
School of Medicine,
6: Department of Plastic Surgery
School of Medicine,
7: Cellular and Molecular Research Center
1,2,4-7: Iran University of Medical Sciences,
Tehran – Iran.
Correspondence
Mehdi Mehdizadeh,
Dept. of Anatomy, School of Medicine ,
Iran University of Medical Sciences,
Tehran – Iran.
E-mail: maranaoo2004@yahoo.com
* Received for Publication: April 30, 2007
* Revision Received: May 15, 2007
* Revision Accepted: August 30, 2007
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