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ISSN 1681-715X |
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Volume 26 |
October - December 2010 |
Number 4 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 26 |
October - December 2010 |
Number 4 |
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Serum Zinc Level in Thalassemia Major
Bijan Keikhaei1, Mohammad Badavi2, Mohammad Pedram3,
Khodamorad Zandian4, Fakher Rahim5ABSTRACT
Objective: To compare serum zinc level between Thalassemia Major (TM) patients and normal population at Shafa Hospital in South West of Iran.
Methodology: A total of 25 male and 36 female of TM patients were enrolled in this study. Out of 61 patients thirty were treated by deferroxamine (DFO) and 31 were on the combination of DFO and deferiprone (DEF) protocol therapy. Sixty normal subjects of the matching age and gender were recruited as controls. From each patient and control group 2 ml of blood was taken in fasting condition. Cell blood count and serum zinc were carried out for both thalassemia patients and normal subjects.
Results: The mean age of patients and control group was 15±5years. Mean serum zinc level was 68.97±21.12µg/dl, 78.10±28.50 µg/dl, and 80.16±26.54 µg/dl in the TM with DFO, TM with DFO + DEF combination protocol and control group respectively. There was no significant correlation between patients and control group. However 50 percent of TM with DFO, 38.7 percent of TM with DFO + DEF and 32.8 percent of control group had hypozincemia.
Conclusion: Nearly 40 to 50 percent of TM patients and one third of normal subjects are suffering from hypozincemia. This study shows that low level of serum zinc is a health problem in both thalassemia patients and normal population in South West of Iran.
KEY WORDS:
Zinc, Thalassemia Major, Deferroxamine, Deferiprone.Pak J Med Sci October - December 2010 Vol. 26 No. 4 942-945
How to cite this article:
Keikhaei B, Badavi M, Pedram M, Zandian K, Rahim F. Serum Zinc Level in Thalassemia Major. Pak J Med Sci 2010;26(4):942-945
1. Bijan Keikhaei,
2. Mohammad Badavi,
3. Mohammad Pedram,
4. Khodamorad Zandian,
5. Fakher Rahim,
1, 3, 4: Associate Professor and Professor of
Research Center for Thalassemia & Hemoglobinopathy
of Ahvaz Joundishapur University of Medical Science.
2, 5: Associate Professor and M.Sc,
Bioinformatics of Physiology
Research Center of Ahvaz Joundishapur
University of Medical Science.
Correspondence:
Dr. Bijan Keikhaei,
AHVAZ - IRAN.
E-mail: keikhaeib@yahoo.com
* Received for Publication: April 15, 2010
* First Revision Received: April 16, 2010
* Second Revision Received: July 23, 2010
* Final Revision Accepted: July 25, 2010
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