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Volume 23 |
October - December 2007 (Part-II) |
Number 6 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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Volume 23 |
October - December 2007 (Part-II) |
Number 6 |
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Comparison of two chemotherapy regimen:
Doxycycline-rifampicin and doxycycline cotrimoxazol
in the brucellosis patients Ahvaz, Iran, 2004-2006
S.M. Alavi1, Ali reza Rajabzadeh2
ABStract
Objective: To compare two drugs regimen, doxycycline-rifampicin and doxycycline-cotrimoxazol in the treatment of brucellosis patients
Methodology: It is a comparative clinical study conducted in Ahwaz a city southwest Iran, from April 2004 to January 2006. This study was conducted on 102 nomads’ patients with brucellosis. The diagnostic criteria were the finding of >1/80 (Wright) with a 2 mercaptoethanol (2 ME) >1/40, in association with compatible clinical findings (back pain, sweating and fever). Patients were enrolled into the two antimicrobial therapy groups, doxycycline plus rifampicin (DR group) and doxycycline plus co-trimoxazole (DC group). The data in the two groups were statistically compared with SPSS by chi square test.
Results: Failure of treatment was seen in one (1.94%) and 5 (9.81%) cases treated in the DC group and DR group, respectively. Relapse was seen in three cases (5.88%) treated in the DC group and in six cases (11.76%) treated in the DR group. Failure of treatment plus relapse was seen in four (7.84%) and 11 (21.56%) cases treated in the DC group and DR group, respectively (p <0.05). Risk for relapse and failure of treatment in DR group was 2.75 times higher than DC group.
Conclusion: This study showed that co-trimoxazole plus doxycycline regimen has a better therapeutic effect than doxycycline plus rifampicin regimen.
KEYWORDS: Chemotherapy, Co-trimoxazole, Doxycycline, Brucellosis.
Pak J Med Sci October - December 2007 (Part-II) Vol. 23 No. 6 889-892
1. Dr. Seyed Mohammad Alavi, MD
2. Dr. Alireza Rajabzadeh, MD
1-2: Joundishapoor Infectious and Tropical
Diseases Research Center,
Infectious disease ward in Razi Hospital,
Razi Hospital,
Affiliated to Joundishapour University
of Medical Sciences,
Ahvaz, Iran.
Correspondence
Dr. Seyed Mohammad Alavi,
Razi Hospital,
Infectious Diseases Ward,
Ahvaz, Iran
Email: alavi1329dr@yahoo.com
* Received for Publication: July 7, 2007
* Revision Received: September 10, 2007
* Revision Accepted: September 15, 2007
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