Pakistan Journal of Medical Sciences

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ORIGINAL ARTICLE

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Volume 23

October - December 2007 (Part-II)

Number  6


 

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Mitoxantrone plus cytarabine versus daunorubicin
plus cytarabine as induction therapy for previously
untreated adult patients with acute myeloid leukemia

Alireza Nikanfar1, Iraj Asvadi2, Jalil Vaez3

ABSTRACT

Objective: The aim of this study was to evaluate the efficacy of mitoxantrone versus daunorubicin on the response rates of acute myeloid leukemia (AML) patients.

Methodology: In this prospective randomized trial, adult patients with newly diagnosed AML received daunorubicin(45mg/m²/d for 3 days) or mitoxantrone (12mg/m²/d for 3 days), each combined with the identical dose of cytarabine(ara-c) (150mg/m²/d by continuous infusion for 7 days). Of 27 patients, 10 were randomly allocated to the mitoxantrone plus ara-c "MA" treatment arm and 17 to the daunorubicin plus ara-c "DA" treatment arm.

Results: Median age of the patients in MA was18 years and in DA was 25. Fifty percent of the MA achieved complete remission and 40% achieved a partial remission giving an overall response rate of %90. The same overall response rate was significantly lower in DA group (P=0.025).

Conclusion: The combination of mitoxantrone and ara-c is a possible alternative to daunorubicin and ara-c combination for the treatment of AML.

KEY WORDS: Mitoxantrone, Cytarabine, AML.

Pak J Med Sci    October - December 2007 (Part-II)    Vol. 23 No. 6    909-912


1. Dr. Alireza Nikanfar,
Assistant Professor of Internal Medicine,
2. Dr. Iraj Asvadi,
Professor of Internal Medicine,
3. Dr. Jalil Vaez,
Professor of Internal Medicine,
1-3: Hematologist & Oncologist,
Hematology & Oncology Research Center,
Tabriz University of Medical Sciences. Tabriz – Iran.

Correspondence

Dr. Alireza Nikanfar,
Email: Nikanfarar@hotmail.com;
horc_tums@yahoo.com

* Received for Publication: April 30, 2007
* Revision Accepted: August 12, 2007



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