Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

HOME   |   SEARCH   |   CURRENT ISSUE   |   PAST ISSUES

-

ORIGINAL ARTICLE-

-

Volume 23

October - December 2007 (Part-II)

Number  6


 

Full Text
PDF of this Article

Investigation of protective effect of prednisolone in
nephropathy induced by co-trimoxazole in rat

Alireza Mozaffari1, Iran Rashidi2

ABSTRACT

Objectives: Co-trimoxazole is a sulfonamide derivative, which is used as an antibacterial drug. Prednisolone is a dermo-corticostroid derivative, which is widely used as an anti-inflammatory and in the treatment of allergic reaction and collagen vascular diseases. The aim of this study was to find out the effect of co-trimoxazole on the renal interstitum and protective effect of predenisolone in rat.

Methodology: Four groups of animal were selected, namely A, B, C and control group. Groups A and B were treated with co-trimoxazole (150mg/Kg sulfa methoxazole + 30mg/Kg trimethoprim) while group C was treated with Co-trimoxazole and prednisolone (4mg/Kg) for 10 days. The reference group only received some dose of water. The blood samples were collected from groups A and C, 24 hours and from group B, 14 days after the last dose of drug were administrated. Microscopic samples from kidney tissue were prepared. The slides staining was done with Hematoxelin and Eosine (H&E) stain for histopathological study.

Results: The creatinine level in serum of group A (1.54) showed a significant increase as compared with the control group (1.04). In the group that received co-trimoxazole the histopathological study showed acute interstitial nephritis (AIN). In the group that was treated with co-trimoxazole + prednisolone showed no histopathological changes.

Conclusion: The results from present study, support the theory that AIN is drug allergic reaction when co-trimoxazole is used.

KEY WORDS: Co-trimoxazole, Predniosolone, Rat, Histopathology, Creatinine.

Pak J Med Sci    October - December 2007 (Part-II)    Vol. 23 No. 6    847-850


1. Dr. Alireza Mozaffari
Department of Internal Medicine,
Golestan University Hospital, School of Medicine,
2. Dr. Iran Rashidi
Department of Pathology, School of Medicine,
1,2: Ahwaz Jondishapour University of Medical Sciences
Ahwaz – Iran.

Correspondence

Dr. Alireza Mozaffari
E. mail: ali_mozaffari2003@yahoo.com

* Received for Publication: June 4, 2007
* Revision Received: October 2, 2007
* Revision Accepted: October 16, 2007



HOME   |   SEARCH   |   CURRENT ISSUE   |   PAST ISSUES

Professional Medical Publications
Room No. 522, 5th Floor, Panorama Centre
Building No. 2, P.O. Box 8766, Saddar, Karachi - Pakistan.
Phones : 5688791, 5689285 Fax : 5689860
pjms@pjms.com.pk