Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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REVIEW ARTICLE

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Volume 23

October - December 2007 (Part-II)

Number  6


 

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The clinical utility of montelukast in
paediatric respiratory diseases

Muslim Mohammed Al-Saadi1

ABSTRACT

The arachidonic acid metabolism via 5-lipoxygenase gives rise to a family of biologically active lipids known as leukotrienes. The role of cysteinyl leukotrienes in the pathogenesis of bronchial asthma is well established. Randomized controlled trials (RCTs) have confirmed the efficacy of leukotriene receptor antagonists (LTRAs), when used as monotherapy or added to inhaled corticosteroids (ICS), in improving bronchial outcome including lung function, symptoms, bronchial asthma exacerbation and health related quality of life. Although, current guidelines place LTRAs as therapeutic option at a range of levels of bronchial asthma severity, there is uncertainty among clinicians about their role in relation to other therapies. Montelukast is a potent, specific, oral cystinyl leukotrine1 (cysLT1) receptor antagonist which improves bronchial asthma control and reduces inhaled corticosteroids requirement.c This review provides an overview of evidence for the use of montelukast in patients with bronchial asthma and exercise induced asthma sleep disorder, respiratory syncytial virus (RSV), bronchiolitis and cystic fibrosis.

KEY WORDS: Montelukast, bronchial asthma, exercise-induced asthma, respiratory syncytial virus, Bronchiolitis, allergic rhinitis, sleep disordered breathing.

Pak J Med Sci    October - December 2007 (Part-II)    Vol. 23 No. 6    962-969


1. Muslim Mohammed Al-Saadi, MBBS, ABP, FCCP
Department of Pediatrics,
College of Medicine & King Khalid University Hospital,
King Saud University Riyadh,
SAUDI ARABIA.

Correspondence

Dr. Muslim Mohammed Al –Saadi,
Assistant Professor,
Department of Pediatrics (39) and Vice Dean,
College of Medicine & King Khalid University Hospital,
King Saud University,
P.O. Box 2925, Riyadh 11461,
Saudi Arabia.
Email: alsaadi@ksu.edu.sa

* Received for Publication : August 29, 2007
* Revision Received : September 3, 2007
* Revision Accepted : November 17, 2007



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