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Volume 23 |
October - December 2007 (Part-II) |
Number 6 |
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Volume 23 |
October - December 2007 (Part-II) |
Number 6 |
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Apoptosis at a glance: Death or life?
Mohammad Derakhshan1
ABSTRACT
Apoptosis or programmed cell death that is genetically regulated is a process for killing cells. It is essential for the normal function of organisms and therefore variety of diseases including autoimmunity and cancer result from any defect in this physiological process. Two pathways are responsible for signalling apoptosis: intrinsic or mitochondrial pathway and extrinsic or death receptor pathway. As a final result of this process, cell destruction activated by a family of cysteine proteases (caspases) takes place. This article summarizes current knowledge of apoptosis.
Key words: Apoptosis, Caspases, Mitochondria.
Pak J Med Sci October - December 2007 (Part-II) Vol. 23 No. 6 979-982
1. Mohammad Derakhshan, MD. PhD,
Associate Professor of Virology,
Department of Virology and Buali Research Institute,
Mashhad University of Medical Sciences (MUMS),
Mashhad – Iran.
Correspondence
Mohammad Derakhshan, MD. PhD
Email: derakhsham@mums.ac.ir
m.derakhshanmd@yahoo.com
* Received for Publication: February 20, 2007
* Revision Received: February 27, 2007
* Revision Accepted: October 16, 2007
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