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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 24 |
October - December 2008 (Part-II) |
Number 6 |
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Helicobacter pylori and peptic
ulcer in cirrhotic patients
Monireh Rahimkhani1, Hadi Ghofrani2
ABSTRACT
Objective: H.pylori infection increases the risk of peptic ulcer in cirrhotic patients.
The role of H.pylori in inducing peptic ulcer disease in chronic liver disease patients remains controversial. The objective was to see if etiology of peptic ulcer in cirrhotic patients is related to H.pylori infection.
Methodology: Sixty cirrhotic patients were enrolled in the study. Peptic ulcer was detected in patients by means endoscope. Sera from patients were tested for Helicobacter pylori antibodies by a commercial ELISA kit. t student and fisher test was used for statistical analysis.
Results: Active peptic ulcer was detected in nine cirrhotic patients. Of the nine patients with peptic ulcer eight (88.9%) tested positive for Helicobacter pylori antibodies and of the remaining 51 patients, 31(60.8%) tested positive for Helicobacter pylori antibodies.
Conclusion: Helicobacter pylori infections in our series of cirrhotic patients with peptic ulcer seems to show the same pattern as described in cirrhotic patients without peptic ulcer (P=0.078). The suggestion that the etiology of the peptic ulcer in cirrhotic patients could be related to Helicobacter pylori infection was not confirmed by our study.
KEY WORDS: H.pylori, Peptic ulcer, Cirrhosis.
Pak J Med Sci October - December 2008 (Part-II) Vol. 24 No. 6 849-852
How to cite this article:
Rahimkhani M, Ghofrani H. Helicobacter pylori and peptic ulcer in cirrhotic patients. Pak J Med Sci 2008;24(6):849-52.
1. Monireh Rahimkhani MD, Ph.D
Faculty of Allied of Medical Sciences,
Tehran University of Medical Sciences,
Ghods st, Poorsina st,
Tehran, Iran.
2. Hadi Ghofrani, MD, Ph.D
Department of Gastroentrology and Endoscopy,
Emam Hospital,
Tehran, Iran.
Correspondence
Monireh Rahimkhani,
E-mail:
rrahimkhani@sina.tums.ac.ir
* Received for Publication: May 8, 2008
* Revision Received: August 8, 2008
* Revision Accepted: August 18, 2008
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