The effect of Statins on outcome of Cerebral Ischemic Stroke | Masoud | Pakistan Journal of Medical Sciences Old Website

The effect of Statins on outcome of Cerebral Ischemic Stroke

Seyed Ali Masoud


Objective: Cerebral ischemic stroke (CIS) is common in elderly. Statins seem to be effective in decreasing the disability caused by CIS. The aim of study was to define the effect of statins on the short-term outcome of CIS.
Methodology: All CIS patients admitted in Shahid Beheshti Kashan Hospital confirmed by the clinical and paraclinical findings during 2010 were enrolled. Cases consisted of those using statins at least three months before the CIS, and controls did not use statins ever. Motor activity was measured based on Modified Rankin Scale (MRS). The MRS was compared at admission with the time of discharge from hospital. Poor outcome was defined if the motor condition would not change or become worse.
Results: Two hundred and thirty CIS patients (103 women) with mean age of 71.59 years were included. The numbers of patients with MRS score less than four was significantly higher in statin group than controls at the time of admission and also at discharge. (All P values < 0.001) The numbers of patients with poor outcome was significantly lower in statin group than controls. (P value < 0.001) The results were similar when the statin and control groups were adjusted for hypercholestrolemia.
Conclusion: Short-term outcome in patients taking statins before CIS was better than those who had never taken statins. It seems reasonable to recommend statin to lower motor disability and better outcome in patients with high risk for developing CIS.

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