Immune status of children with obstructive sleep apnea/hypopnea syndrome
Objective: We aimed to evaluate the immune status of children with obstructive sleep apnea/hypopnea syndrome (OSAHS).
Methods: Fifty children with OSAHS having the symptoms of â€œsnoring, mouth breathing and suffocating during sleepâ€, who were admitted in our hospital from May 2014 to May 2016, were randomly selected. Another 52 healthy, age- and gender-matched children were enrolled as control subjects after taking informed consent. After admission, the peripheral venous blood was collected. T cell subsets and cytokines were analyzed by flow cytometry. Immunoglobulin and complement levels were detected by immunoassay analyzer.
Results: The percentage of CD8+ T lymphocytes in children with OSAHS was (26.47 Â± 1.52)% which was significantly higher than that of control group ((21.94 Â± 1.92)%) (P<0.05). OSAHS group had a significantly lower CD4+/CD8+ ratio (1.24 Â± 0.12) than that of control group (1.45 Â± 0.11) (P<0.05). The two groups had similar percentages of CD3+ and CD4+ T lymphocytes (P>0.05). OSAHS group had significantly higher serum levels of IL-4, IL-6, IL-10 and IFN-Î³ than those of control group (P<0.05), but their IL-2 and TNF-Î± levels were similar (P>0.05). The serum IgA and C3 levels of OSAHS group significantly exceeded those of control group (P<0.05), but their IgG, IgM and C4 levels were similar (P>0.05).
Conclusion: Children with OSAHS had increased percentage of CD8+ T lymphocytes and decreased CD4+/CD8+ ratio, suggesting this group had poor immune function. Increase in humoral immune-related indices IL-4, IL-6, IL-10 and IFN-Î³ indicated the occurrence of oxidative stress and systemic inflammatory status.
How to cite this:Zhang Z, Wang C. Immune status of children with obstructive sleep apnea/hypopnea syndrome. Pak J Med Sci. 2017;33(1):195-199. Â Â doi: https://doi.org/10.12669/pjms.331.11959
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