Can hematologic parameters predict treatment of ectopic pregnancy? | Akkaya | Pakistan Journal of Medical Sciences Old Website

Can hematologic parameters predict treatment of ectopic pregnancy?

Hatice Akkaya, Gülsüm Uysal


Objective: Ectopic pregnancy (EP) is the major cause of maternal morbidity and mortality in the first trimester of pregnancy. EP can be treated either medical or surgical approches. The purpose of our study was to predict the treatment choice of tubal EP by using hematologic parameters which are routinely used in clinical practice.

Methods: After retrospectively data evaluation was done from Januaryu 2014 to Deceber 201. we had 153 patients with EP. Patients admitted to methotrexate (MTX) therapy was Group-1. Patients performed surgery was Group-II. All patients’ initial values including white blood cell (WBC), hemoglobin (Hgb), mean corpuscular volume (MCV), neutrophil and lymphocyte, neutrophil lymphocyte ratio (NLR), platelet, platelet lymphocyte ratio (PLR), red cell distribution width (RDW), platelet distribution width (PDW) and mean platelet volume (MPV) were recorded and compared between groups.

Results: Of 153 EP patients, there were 93 patients in MTX group and 60 patients in surgery group. RDW, MPV were significantly increased in MTX group (p=0.003, p=0.001, p=0.038, respectively). However, no statistically significant difference was observed between the groups in terms of WBC, Hgb, MCV, PLT, PLR, PDW.

Conslusion: RDW, MPV values were independently associated with MTX therapy. Hematologic parameters can be helpful in the choice of the EP treatment. 


How to cite this:Akkaya H, Uysal G. Can hematologic parameters predict treatment of ectopic pregnancy?. Pak J Med Sci. 2017;33(4):937-942.   doi:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Full Text: PDF


  • There are currently no refbacks.