Congenital Hypothyroidism in Neonates of a Tertiary Care Hospital

Abstract

Objective: To determine  neonatal congenital hypothyroidism among neonates born in a tertiary care hospital of Lahore Pakistan.

Methods: This cross-sectional study was carried out at Pathology Department of Allama Iqbal Medical College, Lahore in collaboration with Pediatrics and Gynecology & Obstetrics Department, Jinnah Hospital, Lahore Pakistan. A total of 770 babies were included in this study, both male and female.  About 2 ml venous blood samples were collected aseptically from the neonates in sterile clotted tube. Serum was separated and serum TSH was determined by ELISA method.

Results: Out of total 770 neonates, 48.9% were female and 51.0% were males with the ratio of 1:1.04. Neonatal congenital hypothyroidisim (TSH, >30 mIU/L), was observed in 0.4% (Frequency, 1:257) nenates, with the incidence rate of 1:257. Female to male ratio of hypothyroid neonates was 2:1. The mode of delivery vise distribution showed, among n=251 neonates born by normal delivery, only a single case of hypothyroidism was detected, and among n=519 neonates delivered by cesarean section, only two neonates were belong to hypothyroidism.

Conclusion: The frequency of  Congenital Hypothyroidism is notably higher in pediatric community than reported in most other countries. This result emphasizes the necessity of a nationwide screening program.

doi: https://doi.org/10.12669/pjms.335.12986

How to cite this:Ahmad A, Wasim A, Hussain S, Saeed M, Ahmad BM, Khalil-ur-Rehman. Congenital Hypothyroidism in Neonates of a Tertiary Care Hospital. Pak J Med Sci. 2017;33(5):1269-1272.   doi: https://doi.org/10.12669/pjms.335.12986

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